Four aims are proposed: (1) to explore the role of mapmodulin in living cells by determining the consequences of overexpression, reduced expression or antibody sequestration; (2) to explore a possible link between cytoplasmic dynein and mapmodulin; (3) to carry out invitro experiments to examine the influence of mapmodulin on dynein- or kinesin- mediated microtubule gliding; and ($) to further characterize a new Golgi-specific dynein and a novel Golgi-microtubule linking factor.
| Itin, C; Ulitzur, N; Muhlbauer, B et al. (1999) Mapmodulin, cytoplasmic dynein, and microtubules enhance the transport of mannose 6-phosphate receptors from endosomes to the trans-golgi network. Mol Biol Cell 10:2191-7 |
| Ulitzur, N; Humbert, M; Pfeffer, S R (1997) Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. Proc Natl Acad Sci U S A 94:5084-9 |
