Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050863-02
Application #
2189006
Study Section
Molecular Biology Study Section (MBY)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Rigo, Frank; Martinson, Harold G (2009) Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing. RNA 15:823-36
Rigo, Frank; Martinson, Harold G (2008) Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage. Mol Cell Biol 28:849-62
Nag, Anita; Narsinh, Kazim; Martinson, Harold G (2007) The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase. Nat Struct Mol Biol 14:662-9
Nag, Anita; Narsinh, Kazim; Kazerouninia, Amir et al. (2006) The conserved AAUAAA hexamer of the poly(A) signal can act alone to trigger a stable decrease in RNA polymerase II transcription velocity. RNA 12:1534-44
Rigo, Frank; Kazerouninia, Amir; Nag, Anita et al. (2005) The RNA tether from the poly(A) signal to the polymerase mediates coupling of transcription to cleavage and polyadenylation. Mol Cell 20:733-45
Park, Noh Jin; Tsao, David C; Martinson, Harold G (2004) The two steps of poly(A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domain. Mol Cell Biol 24:4092-103
Kim, Steven J; Martinson, Harold G (2003) Poly(A)-dependent transcription termination: continued communication of the poly(A) signal with the polymerase is required long after extrusion in vivo. J Biol Chem 278:41691-701
Orozco, Ian J; Kim, Steven J; Martinson, Harold G (2002) The poly(A) signal, without the assistance of any downstream element, directs RNA polymerase II to pause in vivo and then to release stochastically from the template. J Biol Chem 277:42899-911
Tran, D P; Kim, S J; Park, N J et al. (2001) Mechanism of poly(A) signal transduction to RNA polymerase II in vitro. Mol Cell Biol 21:7495-508
Chao, L C; Jamil, A; Kim, S J et al. (1999) Assembly of the cleavage and polyadenylation apparatus requires about 10 seconds in vivo and is faster for strong than for weak poly(A) sites. Mol Cell Biol 19:5588-600

Showing the most recent 10 out of 11 publications