Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053936-01
Application #
2193334
Study Section
Molecular Biology Study Section (MBY)
Project Start
1996-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Salehi-Ashtiani, Kourosh; Luptak, Andrej; Litovchick, Alexander et al. (2006) A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science 313:1788-92
Carothers, James M; Davis, Jonathan H; Chou, James J et al. (2006) Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA 12:567-79
Carothers, James M; Oestreich, Stephanie C; Szostak, Jack W (2006) Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc 128:7929-37
Ichida, Justin K; Zou, Keyong; Horhota, Allen et al. (2005) An in vitro selection system for TNA. J Am Chem Soc 127:2802-3
Shen, Xinchun; Valencia, C Alexander; Szostak, Jack W et al. (2005) Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A 102:5969-74
Plummer, Kelly A; Carothers, James M; Yoshimura, Masahiro et al. (2005) In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res 33:5602-10
Zou, Keyong; Horhota, Allen; Yu, Biao et al. (2005) Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org Lett 7:1485-7
Horhota, Allen; Zou, Keyong; Ichida, Justin K et al. (2005) Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc 127:7427-34
Ichida, Justin K; Horhota, Allen; Zou, Keyong et al. (2005) High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res 33:5219-25
Sazani, Peter L; Larralde, Rosa; Szostak, Jack W (2004) A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc 126:8370-1

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