The central hypothesis of the proposal is that PLDs are important regulators of cell biological processes. More specifically, the P.I. proposes that PLD1 regulates secretion in response to stimulation and that PLD2 plays a role in receptor-mediated recycling or secretion.
The specific aims address the central hypothesis.
Aims 1 and 3 deal mainly with the molecular biology, enzymology, and activation of the PLDs, while Aims 2 and 4 deal more directly with the functions of the PLDs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054813-04
Application #
6342922
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Jones, Warren
Project Start
1998-01-01
Project End
2002-12-31
Budget Start
2001-01-01
Budget End
2002-12-31
Support Year
4
Fiscal Year
2001
Total Cost
$250,954
Indirect Cost
Name
State University New York Stony Brook
Department
Pharmacology
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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