Motion is central and essential to life. During the past several decades enormous effort has been invested in attempting to learn how biological motors such as muscles, flagella and cilia operate. But even now there is little understanding, at least at the atomic level of detail, how chemically powered motors achieve directed motion. The PI now proposes to construct a molecular motor that may provide some insight into how biological and other molecular scaled motors work. The motor will operate as a single molecule and is powered by coupling unidirectional molecular movement with the energy released in the hydrolysis of phosgene to carbon dioxide and HCl. The project will entail synthesis and evaluation at several levels of complexity, starting with a demonstration of principle stage and culminating in a fully functioning version, with feedback at each step serving to refine the design of the next stage. The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056262-02
Application #
2750159
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1997-08-01
Project End
2001-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Kelly, T Ross; Cai, Xiaolu; Damkaci, Fehmi et al. (2007) Progress toward a rationally designed, chemically powered rotary molecular motor. J Am Chem Soc 129:376-86
Kelly, T Ross (2005) Molecular motors: synthetic DNA-based walkers inspired by kinesin. Angew Chem Int Ed Engl 44:4124-7
Kelly, T Ross; Cavero, Marta (2002) Selective Monoacylation of a Diamine Using Intramolecular Delivery by a DMAP Unit. Org Lett 4:2653-6
Kelly, T R; Cavero, M; Zhao, Y (2001) Facile metal-assisted hydrolysis of a urethane. Org Lett 3:3895-8
Kelly, T R (2001) Progress toward a rationally designed molecular motor. Acc Chem Res 34:514-22