Motion is central and essential - to life. During the past several decades enormous effort has been invested in attempting to learn how biological motors - such as muscles, flagella and cilia - operate. But even now there is little understanding, at least at the atomic level of detail, how chemically powered motors achieve directed motion. We now propose to construct a rationally designed molecular motor that may provide some insight into how biological - and other - molecular scale motors work. The motor operates as a single molecule and is powered by coupling unidirectional molecular movement with the energy released in the hydrolysis of phosgene to carbon dioxide and HCI. In the initial period of this project we achieved two functioning prototypes of the first non-natural, chemically powered molecular motor. We now propose to complete the task by elaborating the prototypes into fully operational, continuously rotating systems. The project will entail synthesis and evaluation at several levels of complexity, building on the knowledge gained from the work with the prototypes and culminating in a fully functioning version, with feedback at each step serving to refine the design of the next stage. The project should expand the understanding of chemically directed and controlled movement, which is a topic central to the understanding of biological systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056262-08
Application #
6794008
Study Section
Special Emphasis Panel (ZRG1-SSS-B (01))
Program Officer
Schwab, John M
Project Start
1997-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2006-07-31
Support Year
8
Fiscal Year
2004
Total Cost
$289,170
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Kelly, T Ross; Cai, Xiaolu; Damkaci, Fehmi et al. (2007) Progress toward a rationally designed, chemically powered rotary molecular motor. J Am Chem Soc 129:376-86
Kelly, T Ross (2005) Molecular motors: synthetic DNA-based walkers inspired by kinesin. Angew Chem Int Ed Engl 44:4124-7
Kelly, T Ross; Cavero, Marta (2002) Selective Monoacylation of a Diamine Using Intramolecular Delivery by a DMAP Unit. Org Lett 4:2653-6
Kelly, T R; Cavero, M; Zhao, Y (2001) Facile metal-assisted hydrolysis of a urethane. Org Lett 3:3895-8
Kelly, T R (2001) Progress toward a rationally designed molecular motor. Acc Chem Res 34:514-22