This investigator has identified a novel gene, cdc12, in S. pombe that appears to play an important role in the assembly and placement of the contractile ring. He hypothesizes that during interphase, cdc12 exists in a large multiprotein complex that travels along microtubules to the middle of the cell to mark the future site of the cleavage furrow. During mitosis, the cdc12 protein is hypothesized to participate in actin ring assembly through an interaction with the actin-binding protein profilin. Dr. Chang's immediate goal is to test these hypotheses.
Three specific aims are proposed: (1) to determine the function of the interaction between cdc12 and cdc3 (profilin); (2) to identify and characterize additional proteins that interact with cdc12p; and (3) to investigate the spatial aspects of ring formation by examining ring formation in living cells.
| Odermatt, Pascal D; Arjes, Heidi A; Chang, Fred et al. (2018) Who's Your DadA? d-Alanine Levels Regulate Bacterial Stiffness. MBio 9: |
| Rojas, Enrique R; Billings, Gabriel; Odermatt, Pascal D et al. (2018) The outer membrane is an essential load-bearing element in Gram-negative bacteria. Nature 559:617-621 |
| Chang, Fred (2017) Forces that shape fission yeast cells. Mol Biol Cell 28:1819-1824 |
| Atilgan, Erdinc; Magidson, Valentin; Khodjakov, Alexey et al. (2015) Morphogenesis of the Fission Yeast Cell through Cell Wall Expansion. Curr Biol 25:2150-7 |
| Zhou, Zhou; Munteanu, Emilia Laura; He, Jun et al. (2015) The contractile ring coordinates curvature-dependent septum assembly during fission yeast cytokinesis. Mol Biol Cell 26:78-90 |
| Basu, Roshni; Munteanu, Emilia Laura; Chang, Fred (2014) Role of turgor pressure in endocytosis in fission yeast. Mol Biol Cell 25:679-87 |
| Haupt, Armin; Campetelli, Alexis; Bonazzi, Daria et al. (2014) Electrochemical regulation of budding yeast polarity. PLoS Biol 12:e1002029 |
| Chang, Fred; Minc, Nicolas (2014) Electrochemical control of cell and tissue polarity. Annu Rev Cell Dev Biol 30:317-36 |
| Chang, Fred; Huang, Kerwyn Casey (2014) How and why cells grow as rods. BMC Biol 12:54 |
| Pan, Kally Z; Saunders, Timothy E; Flor-Parra, Ignacio et al. (2014) Cortical regulation of cell size by a sizer cdr2p. Elife 3:e02040 |
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