Abstract

Our overall aim is to identify and characterize genetic differences that are important to the human response to infection and inflammation. First, we will use in vivo and in vitro models of inflammation to determine the functional impact of single nucleotide polymorphisms (SNPs) in inflammation-related genes. Second, we propose to identify SNPs that will help characterize an individual patient's risk for severe infection and death after injury. This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM066946-03
Application #
6874540
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Somers, Scott D
Project Start
2003-04-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
3
Fiscal Year
2005
Total Cost
$310,780
Indirect Cost

  Institution

Name
University of Washington
Department
Surgery
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Shubin, Nicholas J; Pham, Tam N; Staudenmayer, Kristan Lea et al. (2018) A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury. J Innate Immun 10:202-214
Bhatraju, Pavan K; Mukherjee, Paramita; Robinson-Cohen, Cassianne et al. (2016) Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care 20:372
Parent, Brodie A; Mandell, Samuel P; Maier, Ronald V et al. (2016) Safety of minimizing preoperative starvation in critically ill and intubated trauma patients. J Trauma Acute Care Surg 80:957-63
Thompson, Callie M; Park, Chin H; Maier, Ronald V et al. (2014) Traumatic injury, early gene expression, and gram-negative bacteremia. Crit Care Med 42:1397-405
Thompson, Callie M; Holden, Tarah D; Rona, Gail et al. (2014) Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study. Ann Surg 259:179-85
Meyer, Nuala J; Feng, Rui; Li, Mingyao et al. (2013) IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist. Am J Respir Crit Care Med 187:950-9
Tejera, Paula; Meyer, Nuala J; Chen, Feng et al. (2012) Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. J Med Genet 49:671-80
Meyer, Nuala J; Li, Mingyao; Feng, Rui et al. (2011) ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med 183:1344-53
Hassan, Monique; Pham, Tam N; Cuschieri, Joseph et al. (2011) The association between the transfusion of older blood and outcomes after trauma. Shock 35:3-8
Shalhub, Sherene; Pham, Tam N; Gibran, Nicole S et al. (2009) Tumor necrosis factor gene variation and the risk of mortality after burn injury: a cohort study. J Burn Care Res 30:105-11

Showing the most recent 10 out of 12 publications