Timely detection of severe patient conditions or concerning events and their mitigation remains an important problem in clinical practice. This is especially true in the critically ill patient. Typical computer-based detection methods developed for this purpose rely on the use of clinical knowledge, such as expert-derived rules, that are incorporated into monitoring and alerting systems. However, it is often time-consuming, costly, and difficult to extract and implement such knowledge in existing monitoring systems. The research work in this proposal offers computational, rather than expert-based, solutions that build alert systems from data stored in patient data repositories, such as electronic medical records. Briefly, our approach uses advanced machine learning algorithms to identify unusual clinical management patterns in individual patients, relative to patterns associated with comparable patients, and raises an alert signaling this discrepancy. Our previous studies provide support that such deviations indicate clinically important events at false alert rates belo 50%, which is very promising. We propose to further improve the new methodology, and build a real-time monitoring and alerting system integrated with production electronic medical records. We propose an evaluation of the system using physicians' assessment of alerts raised by our real-time system for intensive-care unit (ICU) patient cases. The project investigators comprise a multidisciplinary team with expertise in critical care medicine, computer science, biomedical informatics, statistical machine learning, knowledge based systems, and clinical data repositories.

Public Health Relevance

There remain numerous opportunities to reduce medical errors in the intensive care unit (ICU). This project develops and evaluates a new clinical monitoring and alerting framework that uses electronic medical records and machine-learning methods to send alerts concerning clinical decisions in the ICU that are unexpected given the clinical context and may represent medical errors.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM088224-07
Application #
9278178
Study Section
Biomedical Computing and Health Informatics Study Section (BCHI)
Program Officer
Marcus, Stephen
Project Start
2009-09-01
Project End
2018-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
7
Fiscal Year
2017
Total Cost
$543,819
Indirect Cost
$190,690
Name
University of Pittsburgh
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Naeini, Mahdi Pakdaman; Cooper, Gregory F (2018) Binary Classifier Calibration Using an Ensemble of Piecewise Linear Regression Models. Knowl Inf Syst 54:151-170
Luo, Zhipeng; Hauskrecht, Milos (2018) Hierarchical Active Learning with Group Proportion Feedback. IJCAI (U S) 2018:2532-2538
Liu, Siqi; Wright, Adam; Hauskrecht, Milos (2017) Change-Point Detection Method for Clinical Decision Support System Rule Monitoring. Artif Intell Med (2017) 10259:126-135
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Luo, Zhipeng; Hauskrecht, Milos (2017) Group-Based Active Learning of Classification Models. Proc Int Fla AI Res Soc Conf 2017:92-97
Xue, Yanbing; Hauskrecht, Milos (2017) Active Learning of Classification Models with Likert-Scale Feedback. Proc SIAM Int Conf Data Min 2017:28-35
Liu, Siqi; Wright, Adam; Sittig, Dean F et al. (2017) Change-Point Detection for Monitoring Clinical Decision Support Systems with a Multi-Process Dynamic Linear Model. Proceedings (IEEE Int Conf Bioinformatics Biomed) 2017:569-572
Liu, Siqi; Wright, Adam; Hauskrecht, Milos (2017) Online Conditional Outlier Detection in Nonstationary Time Series. Proc Int Fla AI Res Soc Conf 2017:86-91
Liu, Zitao; Hauskrecht, Milos (2017) A Personalized Predictive Framework for Multivariate Clinical Time Series via Adaptive Model Selection. Proc ACM Int Conf Inf Knowl Manag 2017:1169-1177
Batal, Iyad; Cooper, Gregory; Fradkin, Dmitriy et al. (2016) An Efficient Pattern Mining Approach for Event Detection in Multivariate Temporal Data. Knowl Inf Syst 46:115-150

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