Embryonic development and differentiation is controlled, directly and indirectly, by changes in the patterns of gene expression. It is of interest to understand regulatory signaling mechanisms, and changes therein, for genes whose activities are related to particular states of embryonic development or differentiation. I propose to investigate members of a multigene family, encoding histones, that are subject to distinct modes of transcriptional regulation during oogenesis and early embryonic development. This gene family provides a convenient model to examine the control of gene expression in embryonic development since they are among the first to be activated in many animal embryos. The major goals of this proposal are to elucidate the gene-proximal regulatory signal required for histone gene transcription early in embryogenesis, to investigate a regulatory transition in histone gene transcription during early embryonic development and to explore the mechanisms underlying the coordinate transcription of representative members of this gene family.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022025-07
Application #
3321264
Study Section
Molecular Biology Study Section (MBY)
Project Start
1986-08-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
7
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030