The long-term objectives of the research proposed are to determine the biological consequences of exposure to ultrasound on mammalian development. The proposed studies will evaluate the effects of ultrasound exposure of the ovary, by means of assessing preimplantation embryonic development in the mouse. Using this model, experiments have been designed to examine the effects of different levels of ultrasound on cell division, DNA synthesis, protein synthesis and the appearance of temporally- regulated cell surface molecules in the early embryo.
| Heyner, S; Abraham, V; Wikarczuk, M L et al. (1990) Effects of ultrasound on DNA and RNA synthesis in preimplantation mouse embryos. Mol Reprod Dev 25:209-14 |
| Rao, G S; Abraham, V; Fink, B A et al. (1990) Biochemical changes in the developing rat central nervous system due to hyperthermia. Teratology 41:327-32 |
| Abraham, V; Ziskin, M C; Heyner, S (1989) Temperature elevation in the rat fetus due to ultrasound exposure. Ultrasound Med Biol 15:443-9 |
| Heyner, S; Abraham, V; Wikarczuk, M L et al. (1989) Effects of ultrasound on ovulation in the mouse. Gamete Res 22:333-8 |
| Miller, M W; Ziskin, M C (1989) Biological consequences of hyperthermia. Ultrasound Med Biol 15:707-22 |
| Ziskin, M C; Petitti, D B (1988) Epidemiology of human exposure to ultrasound: a critical review. Ultrasound Med Biol 14:91-6 |
