Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD027438-05
Application #
2200426
Study Section
Special Emphasis Panel (SRC (10))
Project Start
1991-02-01
Project End
1996-05-31
Budget Start
1995-02-01
Budget End
1996-05-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Washington
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Ngo, L Y; Patil, S D; Unadkat, J D (2001) Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine. Am J Physiol Gastrointest Liver Physiol 280:G475-81
Tuntland, T; Odinecs, A; Pereira, C M et al. (1999) In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus. Am J Obstet Gynecol 180:198-206
Tuntland, T; Odinecs, A; Nosbisch, C et al. (1998) In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens. J Pharmacol Exp Ther 285:54-62
Patil, S D; Unadkat, J D (1997) Sodium-dependent nucleoside transport in the human intestinal brush-border membrane. Am J Physiol 272:G1314-20
Chandrasena, G; Giltay, R; Patil, S D et al. (1997) Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes. Biochem Pharmacol 53:1909-18
Tuntland, T; Nosbisch, C; Unadkat, J D (1997) Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina). J Antimicrob Chemother 40:687-93
Tuntland, T; Nosbisch, C; Baughman, W L et al. (1996) Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina. Am J Obstet Gynecol 174:856-63
Odinecs, A; Pereira, C; Nosbisch, C et al. (1996) Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina). Antimicrob Agents Chemother 40:2423-5
Odinecs, A; Nosbisch, C; Keller, R D et al. (1996) In vivo maternal-fetal pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in pigtailed macaques (Macaca nemestrina). Antimicrob Agents Chemother 40:196-202
Odinecs, A; Nosbisch, C; Unadkat, J D (1996) Zidovudine does not affect transplacental transfer or systemic clearance of stavudine (2',3'-didehydro-3'-deoxythymidine) in the pigtailed macaque (Macaca nemestrina). Antimicrob Agents Chemother 40:1569-71

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