Experiments are designed to gain further insight into BMP signalling pathways during organogenesis.
Aim 1 is to evaluate contributions of BMP7 to cell proliferation, survival, and programmed cell death during eye and kidney development.
Aim 2 is to describe further the ability of BMP7 to regulate inductive tissue interactions during eye and kidney development.
Aim 3 is to examine potentially distinct and overlapping functional roles of divergent BMP family members during eye and kidney development.
|Adams, Derek; Karolak, Michele; Robertson, Elizabeth et al. (2007) Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. Dev Biol 311:679-90|
|Oxburgh, Leif; Robertson, Elizabeth J (2002) Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. Mech Dev 112:207-11|