Abstract

Experiments are designed to gain further insight into BMP signalling pathways during organogenesis.
Aim 1 is to evaluate contributions of BMP7 to cell proliferation, survival, and programmed cell death during eye and kidney development.
Aim 2 is to describe further the ability of BMP7 to regulate inductive tissue interactions during eye and kidney development.
Aim 3 is to examine potentially distinct and overlapping functional roles of divergent BMP family members during eye and kidney development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD034435-05
Application #
6181834
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Klein, Steven
Project Start
1996-08-09
Project End
2001-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$290,553
Indirect Cost

  Institution

Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138

  Publications

Adams, Derek; Karolak, Michele; Robertson, Elizabeth et al. (2007) Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. Dev Biol 311:679-90
Oxburgh, Leif; Robertson, Elizabeth J (2002) Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. Mech Dev 112:207-11