Reading disability (RD), math disability (MD), and attention-deficit/hyperactivity disorder (ADHD) are common disorders of childhood that frequently co-occur, but the developmental etiology of this comorbidity is largely unknown. The proposed project is an extension of the Western Reserve Reading and Math Project and the International Longitudinal Twin Study of Early Reading Development, two longitudinal twin studies that have followed population-based samples of twins since preschool. The twins will complete an extensive battery of measures of reading, math, ADHD, and neuropsychological functioning at the end of ninth grade. These measures will provide important new information regarding the developmental etiology of word reading and more complex reading fluency and comprehension, the developmental stability of DSM-IV symptom dimensions and subtypes of ADHD, and the longitudinal and cross-sectional etiology of covariance between individual differences and extreme scores on measures of reading, math, and ADHD symptoms. The extensive battery of neuropsychological measures will be used to test which neuropsychological functions are uniquely associated with RD, ADHD, or MD and which are shared risk factors across two or more of these domains, and multivariate twin analyses will be conducted to test the etiology of these associations.

Public Health Relevance

Reading disability (RD), math disability (MD), and attention-deficit/hyperactivity disorder (ADHD) are common disorders of childhood that often co-occur due to unknown causes. This study will administer measures of neuropsychological functioning to two large longitudinal studies of twins to assess the genetic, environmental, and neuropsychological factors that lead to stability and change in each disorder and the specific factors that lead to their frequent co-occurrence.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Miller, Brett
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University of Colorado at Boulder
Other Domestic Higher Education
United States
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Leopold, Daniel R; Christopher, Micaela E; Olson, Richard K et al. (2018) Invariance of ADHD Symptoms Across Sex and Age: a Latent Analysis of ADHD and Impairment Ratings from Early Childhood into Adolescence. J Abnorm Child Psychol :
Becker, Stephen P; Willcutt, Erik G (2018) Advancing the study of sluggish cognitive tempo via DSM, RDoC, and hierarchical models of psychopathology. Eur Child Adolesc Psychiatry :
Becker, Stephen P; Burns, G Leonard; Leopold, Daniel R et al. (2018) Differential impact of trait sluggish cognitive tempo and ADHD inattention in early childhood on adolescent functioning. J Child Psychol Psychiatry 59:1094-1104
Malanchini, Margherita; Wang, Zhe; Voronin, Ivan et al. (2017) Reading self-perceived ability, enjoyment and achievement: A genetically informative study of their reciprocal links over time. Dev Psychol 53:698-712
Malanchini, Margherita; Rimfeld, Kaili; Shakeshaft, Nicholas G et al. (2017) The genetic and environmental aetiology of spatial, mathematics and general anxiety. Sci Rep 7:42218
Arnett, Anne B; Pennington, Bruce F; Peterson, Robin L et al. (2017) Explaining the sex difference in dyslexia. J Child Psychol Psychiatry 58:719-727
Wang, Zhe; Soden, Brooke; Deater-Deckard, Kirby et al. (2017) Development in reading and math in children from different SES backgrounds: the moderating role of child temperament. Dev Sci 20:
Lukowski, Sarah L; Rosenberg-Lee, Miriam; Thompson, Lee A et al. (2017) Approximate Number Sense Shares Etiological Overlap with Mathematics and General Cognitive Ability. Intelligence 65:67-74
Peterson, Robin L; Boada, Richard; McGrath, Lauren M et al. (2017) Cognitive Prediction of Reading, Math, and Attention: Shared and Unique Influences. J Learn Disabil 50:408-421
Hart, Sara A; Logan, Jessica A R; Thompson, Lee et al. (2016) A latent profile analysis of math achievement, numerosity, and math anxiety in twins. J Educ Psychol 108:181-193

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