Abstract

The primary goal of this proposal is to maintain and extend the Jackson Laboratory DNA Panel Mapping Resource. This resource utilizes interspecific backcross DNAs from progeny of F1 hybrids between inbred Mus musculus and Mus spretus strains, backcrossed to Mus musculus (BSB Panel) or to Mus spretus (BSS Panel). The Resource supports the scientific community by providing users with the initial reagents for genetic mapping (DNAs and Southern blots). In addition, the Mapping Resource aids users with data analysis and graphical maps placing new markers relative to all others that are mapped in the two Mapping Panels. Haplotype data for locus typings in the BSB and BSS crosses are stored in the DNA Panel Mapping Resource database and are available online to the greater scientific community via the World Wide Web (WWW). The investigators propose to maintain this DNA Panel Mapping Resource, increase the genetic marker density on the maps of both the BSB and BSS DNA panels, to continue to promote the use of the Mapping Resource for genetic and physical mapping studies, and to pursue new ways to conserve the DNA Panel Resource.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
5R01HG000941-06
Application #
2674213
Study Section
Special Emphasis Panel (ZRG2-GNM (03))
Program Officer
Graham, Bettie
Project Start
1993-09-01
Project End
1999-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Didion, John P; Morgan, Andrew P; Clayshulte, Amelia M-F et al. (2015) A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2. PLoS Genet 11:e1004850
Witmer, Philip D; Doheny, Kimberly F; Adams, Marcia K et al. (2003) The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis. Genome Res 13:485-91
Rowe, L B; Barter, M E; Eppig, J T (2000) Cross-referencing radiation hybrid data to the recombination map: lessons from mouse chromosome 18. Genomics 69:27-36
Ko, M S; Threat, T A; Wang, X et al. (1998) Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet 7:1967-78
D'Esposito, M; Matarazzo, M R; Ciccodicola, A et al. (1997) Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet 6:1917-23
Brady, K P; Rowe, L B; Her, H et al. (1997) Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res 7:1085-93
Rowe, L B; Janaswami, P M; Barter, M E et al. (1996) Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X. Mamm Genome 7:886-9
Mohandas, T K; Chen, X N; Rowe, L B et al. (1995) Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7. Genomics 30:594-7
Rowe, L B; Nadeau, J H; Turner, R et al. (1994) Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome 5:253-74
Birkenmeier, E H; Rowe, L B; Crossman, M W et al. (1994) Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. Mamm Genome 5:805-6