Abstract

Detailed genetic and physical maps for the mouse will be essential for supporting and annotating sequence maps. Community backcross and radiation hybrid mapping resources that provide common mapping reagents and associated databases provide the underpinnings to construct these vital reference maps. The primary objectives of this project are 1) to maintain the existing DNA panel mapping resource that supports the development of a high quality, high density genetic map and its associated database, 2) to further develop and support a community database for RH mapping in the mouse and 3) to judiciously map loci that will provide additional cross-referencing between the genetic and radiation hybrid maps that ultimately will allow their integration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
5R01HG000941-08
Application #
6181617
Study Section
Special Emphasis Panel (ZRG1-MGN (01))
Program Officer
Graham, Bettie
Project Start
1993-09-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
8
Fiscal Year
2000
Total Cost
$425,017
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Didion, John P; Morgan, Andrew P; Clayshulte, Amelia M-F et al. (2015) A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2. PLoS Genet 11:e1004850
Witmer, Philip D; Doheny, Kimberly F; Adams, Marcia K et al. (2003) The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis. Genome Res 13:485-91
Rowe, L B; Barter, M E; Eppig, J T (2000) Cross-referencing radiation hybrid data to the recombination map: lessons from mouse chromosome 18. Genomics 69:27-36
Ko, M S; Threat, T A; Wang, X et al. (1998) Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet 7:1967-78
D'Esposito, M; Matarazzo, M R; Ciccodicola, A et al. (1997) Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet 6:1917-23
Brady, K P; Rowe, L B; Her, H et al. (1997) Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res 7:1085-93
Rowe, L B; Janaswami, P M; Barter, M E et al. (1996) Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X. Mamm Genome 7:886-9
Mohandas, T K; Chen, X N; Rowe, L B et al. (1995) Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7. Genomics 30:594-7
Rowe, L B; Nadeau, J H; Turner, R et al. (1994) Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome 5:253-74
Birkenmeier, E H; Rowe, L B; Crossman, M W et al. (1994) Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. Mamm Genome 5:805-6