Computational identification and characterization of constrained elements in the human genome is 1 of the major goals of the next phase of the human genome project (Collins et al. 2003). To generate the requisite comparative sequence data, the sequencing centers will generate whole genome sequence from a number of mammals chosen primarily for their large diversity in terms of neutral substitutions. Currently existing, in production, or scheduled for production are at least 8 mammalian genomes at high coverage and 8 mammalian genomes at 2x coverage (www.genome.gov/12511858). This proposal focuses on the detection and annotation of constrained elements on the basis of global sequence alignments and high-resolution estimates of evolutionary rates. In short, we propose to generate the data that provided the justification for making a large investment in comparative sequencing of diverse mammals.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
5R01HG003685-02
Application #
7117857
Study Section
Genomics, Computational Biology and Technology Study Section (GCAT)
Program Officer
Good, Peter J
Project Start
2005-09-01
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$502,898
Indirect Cost
Name
Stanford University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305