Abstract

The broad aims of this proposal are to elucidate the role of triglyceridecontaining lipoproteins in experimentally produced atheromatosis. Cholesterol influx from chylomicron and chylomicron remnants into rabbit aorta will be compared to that of low density lipoprotein cholesterol. The role of lipoprotein receptors and of endocytosis will be examined. Similar studies in subhuman primates and in cell culture systems will also be pursued. The properties of cholesteryl ester exchange protein in human plasma will be studied and its role in the transfer of cholesteryl ester between lipoproteins with each other and between lipoproteins and cells will be investigated. Studies on lesion progression beyond the fatty streak stage will be performed by combining mechanical injury to the artery with diet modifications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL010933-20
Application #
3334393
Study Section
Metabolism Study Section (MET)
Project Start
1976-05-01
Project End
1985-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Cornell University
Department
Type
Schools of Nutrition
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Quig, D W; Arbeeny, C M; Zilversmit, D B (1991) Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma. Biochim Biophys Acta 1083:257-64
Van Heek, M; Zilversmit, D B (1991) Mechanisms of hypertriglyceridemia in the coconut oil/cholesterol-fed rabbit. Increased secretion and decreased catabolism of very low density lipoprotein. Arterioscler Thromb 11:918-27
Quig, D W; Zilversmit, D B (1990) Plasma lipid transfer activities. Annu Rev Nutr 10:169-93
Van Heek, M; Zilversmit, D B (1990) Postprandial lipemia and lipoprotein lipase in the rabbit are modified by olive and coconut oil. Arteriosclerosis 10:421-9
Zilversmit, D B; Shea, T M (1989) Quantitation of apoB-48 and apoB-100 by gel scanning or radio-iodination. J Lipid Res 30:1639-46
Quig, D W; Zilversmit, D B (1989) High density lipoprotein metabolism in a rabbit model of hyperalphalipoproteinemia. Atherosclerosis 76:9-19
Schwenke, D C; Zilversmit, D B (1989) The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit. 1. Studies during the first two days after mild aortic injury. Atherosclerosis 77:91-103
Minnich, A; Zilversmit, D B (1989) Impaired triacylglycerol catabolism in hypertriglyceridemia of the diabetic, cholesterol-fed rabbit: a possible mechanism for protection from atherosclerosis. Biochim Biophys Acta 1002:324-32
Nordestgaard, B G; Zilversmit, D B (1989) Comparison of arterial intimal clearances of LDL from diabetic and nondiabetic cholesterol-fed rabbits. Differences in intimal clearance explained by size differences. Arteriosclerosis 9:176-83
Schwenke, D C; Zilversmit, D B (1989) The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit. 2. Long-term studies in deendothelialized and reendothelialized aortas. Atherosclerosis 77:105-15

Showing the most recent 10 out of 23 publications