Abstract

Research will continue on the role of plasma triglycerides in atherogenesis. Several models will be studied: Alloxan diabetic rabbit, adrenal corticoid administration, detergent injections. The role of lipoprotein particle size and composition in the rate of liquid uptake and in vivo hydrolysis of fatty acid esters will be examined. We also expect to study a potential role of plasma lipid transfer activity in atherogenesis. Lipid transfer activity in rabbits is high and increases during hypercholesterolemia, whereas the rat has little or no such activity in plasma. Methods for altering the composition of plasma lipoproteins will be developed and in vivo clearance of modified lipoproteins will be compared to the original lipoprotein clearance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL010933-25
Application #
3334397
Study Section
Metabolism Study Section (MET)
Project Start
1976-05-01
Project End
1991-05-31
Budget Start
1990-06-01
Budget End
1991-05-31
Support Year
25
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Cornell University
Department
Type
Other Domestic Higher Education
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Quig, D W; Arbeeny, C M; Zilversmit, D B (1991) Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma. Biochim Biophys Acta 1083:257-64
Van Heek, M; Zilversmit, D B (1991) Mechanisms of hypertriglyceridemia in the coconut oil/cholesterol-fed rabbit. Increased secretion and decreased catabolism of very low density lipoprotein. Arterioscler Thromb 11:918-27
Quig, D W; Zilversmit, D B (1990) Plasma lipid transfer activities. Annu Rev Nutr 10:169-93
Van Heek, M; Zilversmit, D B (1990) Postprandial lipemia and lipoprotein lipase in the rabbit are modified by olive and coconut oil. Arteriosclerosis 10:421-9
Zilversmit, D B; Shea, T M (1989) Quantitation of apoB-48 and apoB-100 by gel scanning or radio-iodination. J Lipid Res 30:1639-46
Quig, D W; Zilversmit, D B (1989) High density lipoprotein metabolism in a rabbit model of hyperalphalipoproteinemia. Atherosclerosis 76:9-19
Schwenke, D C; Zilversmit, D B (1989) The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit. 1. Studies during the first two days after mild aortic injury. Atherosclerosis 77:91-103
Minnich, A; Zilversmit, D B (1989) Impaired triacylglycerol catabolism in hypertriglyceridemia of the diabetic, cholesterol-fed rabbit: a possible mechanism for protection from atherosclerosis. Biochim Biophys Acta 1002:324-32
Nordestgaard, B G; Zilversmit, D B (1989) Comparison of arterial intimal clearances of LDL from diabetic and nondiabetic cholesterol-fed rabbits. Differences in intimal clearance explained by size differences. Arteriosclerosis 9:176-83
Schwenke, D C; Zilversmit, D B (1989) The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit. 2. Long-term studies in deendothelialized and reendothelialized aortas. Atherosclerosis 77:105-15

Showing the most recent 10 out of 23 publications