This grant represents in effect a competitive renewal for 2 grants, HL-18918 (Characterization of Lung Elastin) and HL-15965 (Elastin metabolism in Atherosclerosis).
The specific aims of both grants have been combined and are: 1) to isolate and characterize elastin fiber precursors from lung and aorta sources, 2) quantify changes in elastin synthesis and accumulation (deposition) during lund and aorta development, 3) identify factors that influence elastin metabolism, and 4) identify or clarify post-translation steps important to elastic fiber deposition. The methodologies will involve whole animal, tissue culture, and cell-free translation studies dealing eith elastin biosynthesis in relationship to development, diet, endocrine, and disease model relationships. It is the hope that the findings will have application to concepts inportant to a better understanding of elastin's role in developmental emphysema, other forms of chronic obstructive lung disease and vessel wall development in health and disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL015965-14
Application #
3335078
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1979-05-01
Project End
1987-08-31
Budget Start
1986-05-01
Budget End
1987-08-31
Support Year
14
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Earth Sciences/Resources
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
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