Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL016355-11S1
Application #
3335183
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1977-04-01
Project End
1985-09-29
Budget Start
1984-04-01
Budget End
1985-09-29
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Huang, Z; McGowan, E B; Detwiler, T C (1992) Ester and amide derivatives of E64c as inhibitors of platelet calpains. J Med Chem 35:2048-54
Huang, E M (1992) Different effects of A23187 and PMA on palmitoylated platelet proteins. Thromb Res 68:75-86
Speziale, M V; Detwiler, T C (1990) Free thiols of platelet thrombospondin. Evidence for disulfide isomerization. J Biol Chem 265:17859-67
McGowan, E B; Becker, E; Detwiler, T C (1989) Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem Biophys Res Commun 158:432-5
Huang, E M (1989) Agonist-enhanced palmitoylation of platelet proteins. Biochim Biophys Acta 1011:134-9
Miller, J J; Browne, P C; Detwiler, T C (1988) Complexes of thrombin with secreted platelet proteins. Biochem Biophys Res Commun 151:9-15
Browne, P C; Miller, J J; Detwiler, T C (1988) Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. Arch Biochem Biophys 265:534-8
Huang, E M; Detwiler, T C (1987) Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization. Biochem J 242:11-8
Detwiler, T C; Turk, J L; Browne, P C (1987) Thiol-disulfide exchange by thrombospondin. Semin Thromb Hemost 13:276-80
McGowan, E B; Detwiler, T C (1986) Modified platelet responses to thrombin. Evidence for two types of receptors or coupling mechanisms. J Biol Chem 261:739-46

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