Abstract

For the past several years, the importance of terminal galactose groups in the glycoproteins in platelet interactions has been studied. It was found that platelet aggregation, adhesion and serotonin release are dependent upon the glycoproteins. The current studies include the effect of galactose-immobilized albumin on platelet adhesion and aggregation to verify the previously proposed mechanisms. Immobilized galactose contents and the length of spacer for coupling will be varied for this study. The oligosaccharide groups in the well prepared and characterized fibronection will be tested to verify whether they play an important role in the platelet adhesion on the surfaces.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL017623-12
Application #
3335387
Study Section
(SSS)
Project Start
1974-09-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Kim, S W; Jacobs, H (1996) Design of nonthrombogenic polymer surfaces for blood-contacting medical devices. Blood Purif 14:357-72
Gutowska, A; Bae, Y H; Jacobs, H et al. (1995) Heparin release from thermosensitive polymer coatings: in vivo studies. J Biomed Mater Res 29:811-21
Castner, D G; Ratner, B D; Grainger, D W et al. (1992) Surface characterization of 2-hydroxyethyl methacrylate/styrene copolymers by angle-dependent X-ray photoelectron spectroscopy and static secondary ion mass spectrometry. J Biomater Sci Polym Ed 3:463-80
Grainger, D W; Knutson, K; Kim, S W et al. (1990) Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. II: Surface characterization and in vitro assessments. J Biomed Mater Res 24:403-31
Piao, A Z; Nojiri, C; Park, K D et al. (1990) Synthesis and characterization of poly(dimethylsiloxane)-poly(ethylene oxide)-heparin CBABC type block copolymers. J Biomater Sci Polym Ed 1:299-313
Grainger, D W; Okano, T; Kim, S W et al. (1990) Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. III: Surface and bulk compositional differences. J Biomed Mater Res 24:547-71
Grainger, D W; Nojiri, C; Okano, T et al. (1989) In vitro and ex vivo platelet interactions with hydrophilic-hydrophobic poly(ethylene oxide)-polystyrene multiblock copolymers. J Biomed Mater Res 23:979-1005
Grainger, D W; Kim, S W; Feijen, J (1988) Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. I. Synthesis and characterization. J Biomed Mater Res 22:231-49
Kim, S W (1987) Platelet adhesion and prevention at blood-polymer interface. Artif Organs 11:228-36
Nojiri, C; Okano, T; Grainger, D et al. (1987) Evaluation of nonthrombogenic polymers in a new rabbit A-A shunt model. ASAIO Trans 33:596-601