Abstract

This project is based on the hypothesis that neural mechanisms in the control of respiration are more important than traditionally believed. The studies use the neural output, represented by phrenic or other nerve activity, of the respiratory control system rather than ventilation, allowing use of """"""""open-loop"""""""" experimental conditions. The input-output characteristics of the control system to neural stimuli are being studied. In particular, the studies are looking at 1) ability of the central neural system to maintain its own activity by a reverberatory mechanism is being studied; 2) alinearity in the conversion of input signals to output; 3) the function of the intermediate area (Is) of the ventral surface of the medulla in the processing of central chemoreceptor, carotid body and muscle afferents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL017689-14
Application #
3335394
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
14
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Okada, Yasumasa; Chen, Zibin; Jiang, Wuhan et al. (2004) Functional connection from the surface chemosensitive region to the respiratory neuronal network in the rat medulla. Adv Exp Med Biol 551:45-51
Okada, Yasumasa; Chen, Zibin; Jiang, Wuhan et al. (2002) Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats. J Appl Physiol 93:427-39
Paydarfar, D; Eldridge, F L; Paydarfar, J A (1998) Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats. J Physiol 506 ( Pt 2):515-28
Eldridge, F L (1994) Central integration of mechanisms in exercise hyperpnea. Med Sci Sports Exerc 26:319-27
Eldridge, F L; Chen, Z (1992) Respiratory-associated rhythmic firing of midbrain neurons is modulated by vagal input. Respir Physiol 90:31-46
Chen, Z; Eldridge, F L; Wagner, P G (1992) Respiratory-associated thalamic activity is related to level of respiratory drive. Respir Physiol 90:99-113
Paydarfar, D; Eldridge, F L; Wagner, P G et al. (1992) Neural respiratory responses to cortically induced seizures in cats. Respir Physiol 89:225-37
Wagner, P G; Eldridge, F L; Dowell, R T (1991) Anesthesia affects respiratory and sympathetic nerve activities differentially. J Auton Nerv Syst 36:225-36
Wagner, P G; Eldridge, F L (1991) Development of short-term potentiation of respiration. Respir Physiol 83:129-39
Chen, Z; Eldridge, F L; Wagner, P G (1991) Respiratory-associated rhythmic firing of midbrain neurones in cats: relation to level of respiratory drive. J Physiol 437:305-25

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