Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL037090-11
Application #
2218355
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1986-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Georgia
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Kordula, Tomasz; Banbula, Agnieszka; Macomson, Jeremy et al. (2002) Isolation and properties of stachyrase A, a chymotrypsin-like serine proteinase from Stachybotrys chartarum. Infect Immun 70:419-21
Kasza, A; Rogowski, K; Kilarski, W et al. (2001) Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells. Biochem J 355:307-14
Kordula, T; Bugno, M; Rydel, R E et al. (2000) Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes. J Neurosci 20:7510-6
Cichy, J; Rose-John, S; Travis, J (1998) Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells. Biochem J 329 ( Pt 2):335-9
Kordula, T; Rydel, R E; Brigham, E F et al. (1998) Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes. J Biol Chem 273:4112-8
Kozik, A; Potempa, J; Travis, J (1998) Spontaneous inactivation of human lung tryptase as probed by size-exclusion chromatography and chemical cross-linking: dissociation of active tetrameric enzyme into inactive monomers is the primary event of the entire process. Biochim Biophys Acta 1385:139-48
Korzus, E; Nagase, H; Rydell, R et al. (1997) The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression. J Biol Chem 272:1188-96
Cichy, J; Potempa, J; Travis, J (1997) Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem 272:8250-5
Cichy, J; Rose-John, S; Potempa, J et al. (1997) Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells. J Immunol 159:5648-53
Imamura, T; Dubin, A; Moore, W et al. (1996) Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens. Lab Invest 74:861-70

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