Abstract

This research considers the effect of the extraceullar conducting space on propagation in the adjoining cardiac tissue through the use of electrophysiological/mathematical models and computer simulation. Expected effects include modification of velocity, waveform and safety factor. The quantitative effect is also expected to be different for longitudinal as contrasted with transverse propagation. Simulation will be performed on a multifiber slab and a multifibered cylinder lying in an extensive volume-conduction region. The simulation will be conducted using a bidomain tissuemodel and an Ebihara-Johnson membrane model initially. Following this, the inclusion of the recovery period as well as the effect of discrete junctions will be considered. Conditions to be evaluated include the effect of premature stimulii, and channel blocking drugs as well as variations in the physical size of the tissue, its conductivity parameters, and the membrane parameters.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040609-02
Application #
3357874
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1988-04-01
Project End
1991-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Rich, S S (2001) Introduction: linkage analysis of full-genome screens. Genet Epidemiol 21 Suppl 1:S115-6
Davis, C C; Brown, W M; Lange, E M et al. (2001) Nonparametric linkage regression. II: Identification of influential pedigrees in tests for linkage. Genet Epidemiol 21 Suppl 1:S123-9
Langefeld, C D; Davis, C C; Brown, W M (2001) Nonparametric linkage regression. I: Combined Caucasian CSGA and German genome scans for asthma. Genet Epidemiol 21 Suppl 1:S136-41
Witkowski, F X; Kavanagh, K M; Penkoske, P A et al. (1995) Epicardial cardiac source-field behavior. IEEE Trans Biomed Eng 42:552-8
Barr, R C; Plonsey, R (1995) Threshold variability in fibers with field stimulation of excitable membranes. IEEE Trans Biomed Eng 42:1185-91
Plonsey, R; Barr, R C (1995) Electric field stimulation of excitable tissue. IEEE Trans Biomed Eng 42:329-36
Witkowski, F X; Plonsey, R; Penkoske, P A et al. (1994) Significance of inwardly directed transmembrane current in determination of local myocardial electrical activation during ventricular fibrillation. Circ Res 74:507-24
Henneberg, K; Plonsey, R (1994) Spatial- and frequency-domain ring source models for the single-muscle fibre action potential. Med Biol Eng Comput 32:27-34
Witkowski, F X; Kavanagh, K M; Penkoske, P A et al. (1993) In vivo estimation of cardiac transmembrane current. Circ Res 72:424-39
Henneberg, K A; Plonsey, R (1993) Boundary element analysis of the directional sensitivity of the concentric EMG electrode. IEEE Trans Biomed Eng 40:621-31

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