Abstract

The specific goals are to determine (1) Response of a uniform three-dimensional cardiac muscle bundle to an electric current (defibrillating) impulse. Extension to include more realistic cardiac muscle geometry in the form of an eccentric spheres heart model. Solutions will be examined under subthreshold and transthreshold conditions. The presence and effect of intercellular (coupling) junctional resistances on induced transmembrane potential will be particularly examined. (2) Response of a single-fiber cardiac strand to a magnetic field stimulating pulse. Extension to a uniform three-dimensional cylindrical bundle of cardiac muscle fibers, and then an investigation of the eccentric spheres heart model. Solutions under subthreshold and transthreshold conditions will be examined. The effect of junctional resistances and other discontinuities in conductivity will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040609-06
Application #
2219672
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1988-04-01
Project End
1996-06-30
Budget Start
1993-07-01
Budget End
1996-06-30
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Langefeld, C D; Davis, C C; Brown, W M (2001) Nonparametric linkage regression. I: Combined Caucasian CSGA and German genome scans for asthma. Genet Epidemiol 21 Suppl 1:S136-41
Rich, S S (2001) Introduction: linkage analysis of full-genome screens. Genet Epidemiol 21 Suppl 1:S115-6
Davis, C C; Brown, W M; Lange, E M et al. (2001) Nonparametric linkage regression. II: Identification of influential pedigrees in tests for linkage. Genet Epidemiol 21 Suppl 1:S123-9
Witkowski, F X; Kavanagh, K M; Penkoske, P A et al. (1995) Epicardial cardiac source-field behavior. IEEE Trans Biomed Eng 42:552-8
Barr, R C; Plonsey, R (1995) Threshold variability in fibers with field stimulation of excitable membranes. IEEE Trans Biomed Eng 42:1185-91
Plonsey, R; Barr, R C (1995) Electric field stimulation of excitable tissue. IEEE Trans Biomed Eng 42:329-36
Witkowski, F X; Plonsey, R; Penkoske, P A et al. (1994) Significance of inwardly directed transmembrane current in determination of local myocardial electrical activation during ventricular fibrillation. Circ Res 74:507-24
Henneberg, K; Plonsey, R (1994) Spatial- and frequency-domain ring source models for the single-muscle fibre action potential. Med Biol Eng Comput 32:27-34
Witkowski, F X; Kavanagh, K M; Penkoske, P A et al. (1993) In vivo estimation of cardiac transmembrane current. Circ Res 72:424-39
Henneberg, K A; Plonsey, R (1993) Boundary element analysis of the directional sensitivity of the concentric EMG electrode. IEEE Trans Biomed Eng 40:621-31

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