Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041661-05
Application #
3359500
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1988-12-01
Project End
1993-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Dauber, I M; Parsons, P E; Welsh, C H et al. (1993) Peripheral bypass-induced pulmonary and coronary vascular injury. Association with increased levels of tumor necrosis factor. Circulation 88:726-35
Rubinstein, J D; Lesnefsky, E J; Byler, R M et al. (1992) Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion. Free Radic Biol Med 13:627-34
Carrea, F P; Lesnefsky, E J; Kaiser, D G et al. (1992) The lazaroid U74006F, a 21-aminosteroid inhibitor of lipid peroxidation, attenuates myocardial injury from ischemia and reperfusion. J Cardiovasc Pharmacol 20:230-5
Lesnefsky, E J; Allen, K G; Carrea, F P et al. (1992) Iron-catalyzed reactions cause lipid peroxidation in the intact heart. J Mol Cell Cardiol 24:1031-8
Dauber, I M; Lesnefsky, E J; Ashmore, R C et al. (1992) Coronary vascular injury due to ischemia-reperfusion is reduced by pentoxifylline. J Pharmacol Exp Ther 260:1250-6
Sheridan, F M; Dauber, I M; McMurtry, I F et al. (1991) Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res 69:1566-74
Lesnefsky, E J; Dauber, I M; Horwitz, L D (1991) Myocardial sulfhydryl pool alterations occur during reperfusion after brief and prolonged myocardial ischemia in vivo. Circ Res 68:605-13
Ashmore, R C; Rodman, D M; Sato, K et al. (1991) Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am J Physiol 260:H1929-34
Carrea, F P; Lesnefsky, E J; Repine, J E et al. (1991) Reduction of canine myocardial infarct size by a diffusible reactive oxygen metabolite scavenger. Efficacy of dimethylthiourea given at the onset of reperfusion. Circ Res 68:1652-9
Ashmore, R C; O'Brien, R F; Stelzner, T J et al. (1990) Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. Biochem Biophys Res Commun 166:909-15

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