Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL045206-06
Application #
2222003
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-04-05
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Southern California
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
McLeod, L L; Sevanian, A (1997) Lipid peroxidation and modification of lipid composition in an endothelial cell model of ischemia and reperfusion. Free Radic Biol Med 23:680-94
Rashba-Step, J; Tatoyan, A; Duncan, R et al. (1997) Phospholipid peroxidation induces cytosolic phospholipase A2 activity: membrane effects versus enzyme phosphorylation. Arch Biochem Biophys 343:44-54
Sweetman, L L; Zhang, N Y; Peterson, H et al. (1995) Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys 323:97-107
Watson, A D; Navab, M; Hama, S Y et al. (1995) Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein. J Clin Invest 95:774-82
Verity, M A; Sarafian, T; Pacifici, E H et al. (1994) Phospholipase A2 stimulation by methyl mercury in neuron culture. J Neurochem 62:705-14
Pacifici, E H; McLeod, L L; Sevanian, A (1994) Lipid hydroperoxide-induced peroxidation and turnover of endothelial cell phospholipids. Free Radic Biol Med 17:297-309
Pacifici, E H; McLeod, L L; Peterson, H et al. (1994) Linoleic acid hydroperoxide-induced peroxidation of endothelial cell phospholipids and cytotoxicity. Free Radic Biol Med 17:285-95
Salgo, M G; Corongiu, F P; Sevanian, A (1993) Enhanced interfacial catalysis and hydrolytic specificity of phospholipase A2 toward peroxidized phosphatidylcholine vesicles. Arch Biochem Biophys 304:123-32
Zhang, J R; Sevanian, A (1993) The genotoxic effects of arachidonic acid in V79 cells are mediated by peroxidation products. Toxicol Appl Pharmacol 121:193-202
Wratten, M L; van Ginkel, G; van't Veld, A A et al. (1992) Structural and dynamic effects of oxidatively modified phospholipids in unsaturated lipid membranes. Biochemistry 31:10901-7

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