Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL045724-02S1
Application #
3364832
Study Section
Biochemistry Study Section (BIO)
Project Start
1992-04-09
Project End
1997-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Putkey, John A; Kleerekoper, Quinn; Gaertner, Tara R et al. (2003) A new role for IQ motif proteins in regulating calmodulin function. J Biol Chem 278:49667-70
Kleerekoper, Quinn; Hecht, Jacqueline T; Putkey, John A (2002) Disease-causing mutations in cartilage oligomeric matrix protein cause an unstructured Ca2+ binding domain. J Biol Chem 277:10581-9
Kleerekoper, Q; Putkey, J A (1999) Drug binding to cardiac troponin C. J Biol Chem 274:23932-9
Hazard, A L; Kohout, S C; Stricker, N L et al. (1998) The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements. Protein Sci 7:2451-9
Kleerekoper, Q; Liu, W; Choi, D et al. (1998) Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C. J Biol Chem 273:8153-60
Waxham, M N; Tsai, A L; Putkey, J A (1998) A mechanism for calmodulin (CaM) trapping by CaM-kinase II defined by a family of CaM-binding peptides. J Biol Chem 273:17579-84
Parsons, B; Szczesna, D; Zhao, J et al. (1997) The effect of pH on the Ca2+ affinity of the Ca2+ regulatory sites of skeletal and cardiac troponin C in skinned muscle fibres. J Muscle Res Cell Motil 18:599-609
Putkey, J A; Liu, W; Lin, X et al. (1997) Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ. Biochemistry 36:970-8
Putkey, J A; Waxham, M N (1996) A peptide model for calmodulin trapping by calcium/calmodulin-dependent protein kinase II. J Biol Chem 271:29619-23
Lin, X; Dotson, D G; Putkey, J A (1996) Covalent binding of peptides to the N-terminal hydrophobic region of cardiac troponin C has limited effects on function. J Biol Chem 271:244-9

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