The major goals of the proposed research are to examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over 7 years; to examine the cross-sectional associations between dietary variables and major cardiovascular disease risk factors, to examine changes in dietary behaviors and their determinants over 7 years; and to characterize the influences of dietary behavior changes on risk factor status between 1984-88 and 1991-94. The proposed data collection efforts and cross-sectional analyses will be carried out among approximately 3800 males and females during the scheduled 1991-1994 Cycle V Framingham Offspring/Spouse study. The proposed secular trend and longitudinal analyses will also include data that were collected during the Cycle III Offspring/Spouse studies in 1984-88. Of particular interest are dietary variables which are established to play a major role in serum total cholesterol and lipoprotein regulation. Additional dietary variables which may be associated with major cardiovascular risk factors ((elevated) blood pressure, glucose (in)tolerance, (excess) body weight or physical (in)activity, and smoking) or that may predict CHD endpoints will be included in the analyses. We will consider the potential confounding effects or interactions between dietary and risk factor variables. We intend to carry out separate analyses in males and females.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL046193-01A1
Application #
3365267
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1992-02-01
Project End
1996-01-31
Budget Start
1992-02-01
Budget End
1993-01-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Millen, B E; Quatromoni, P A; Franz, M M et al. (1997) Population nutrient intake approaches dietary recommendations: 1991 to 1995 Framingham Nutrition Studies. J Am Diet Assoc 97:742-9
Posner, B M; Franz, M M; Quatromoni, P A et al. (1995) Secular trends in diet and risk factors for cardiovascular disease: the Framingham Study. J Am Diet Assoc 95:171-9