Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047638-04
Application #
2223823
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1995-02-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Weis Center for Research-Geisinger Clinc
Department
Type
DUNS #
079161360
City
Danville
State
PA
Country
United States
Zip Code
17822
Hannan, R; Stefanovsky, V; Arino, T et al. (1999) Cellular regulation of ribosomal DNA transcription:both rat and Xenopus UBF1 stimulate rDNA transcription in 3T3 fibroblasts. Nucleic Acids Res 27:1205-13
Hannan, R D; Hempel, W M; Cavanaugh, A et al. (1998) Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase. J Biol Chem 273:1257-67
Carey, D J; Conner, K; Asundi, V K et al. (1997) cDNA cloning, genomic organization, and in vivo expression of rat N-syndecan. J Biol Chem 272:2873-9
Kabler, R L; Srinivasan, A; Taylor, L J et al. (1996) Androgen regulation of ribosomal RNA synthesis in LNCaP cells and rat prostate. J Steroid Biochem Mol Biol 59:431-9
Hannan, R D; Luyken, J; Rothblum, L I (1996) Regulation of ribosomal DNA transcription during contraction-induced hypertrophy of neonatal cardiomyocytes. J Biol Chem 271:3213-20
Luyken, J; Hannan, R D; Cheung, J Y et al. (1996) Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes. Hyperphosphorylation of upstream binding factor, an rDNA transcription factor. Circ Res 78:354-61
Hannan, R D; Stefanovsky, V; Taylor, L et al. (1996) Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy. Proc Natl Acad Sci U S A 93:8750-5
Hempel, W M; Cavanaugh, A H; Hannan, R D et al. (1996) The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. Mol Cell Biol 16:557-63
Glibetic, M; Taylor, L; Larson, D et al. (1995) The RNA polymerase I transcription factor UBF is the product of a primary response gene. J Biol Chem 270:4209-12
Hannan, R D; Luyken, J; Rothblum, L I (1995) Regulation of rDNA transcription factors during cardiomyocyte hypertrophy induced by adrenergic agents. J Biol Chem 270:8290-7

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