Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL048322-04S1
Application #
2224396
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-08-17
Project End
1996-03-31
Budget Start
1994-08-01
Budget End
1995-03-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Whinna, H C; Lesesky, E B; Monroe, D M et al. (2004) Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. J Thromb Haemost 2:1127-34
Arruda, V R; Hagstrom, J N; Deitch, J et al. (2001) Posttranslational modifications of recombinant myotube-synthesized human factor IX. Blood 97:130-8
Camire, R M; Larson, P J; Stafford, D W et al. (2000) Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide. Biochemistry 39:14322-9
Larson, P J; Camire, R M; Wong, D et al. (1998) Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles. Biochemistry 37:5029-38
Carew, J A; Pollak, E S; High, K A et al. (1998) Severe factor VII deficiency due to a mutation disrupting an Sp1 binding site in the factor VII promoter. Blood 92:1639-45
Wu, S M; Stafford, D W; Frazier, L D et al. (1997) Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase. Blood 89:4058-62
Ambrosini, G; Plescia, J; Chu, K C et al. (1997) Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J Biol Chem 272:8340-5
Larson, P J; Stanfield-Oakley, S A; VanDusen, W J et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J Biol Chem 271:3869-76
Pollak, E S; Hung, H L; Godin, W et al. (1996) Functional characterization of the human factor VII 5'-flanking region. J Biol Chem 271:1738-47
Chu, K; Wu, S M; Stanley, T et al. (1996) A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism. J Clin Invest 98:1619-25

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