Regulation & Biosynthesis of Vitamin K-Dependent Factors

High, Katherine A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL048322-01
• Application #: 3367483
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1992-04-10
• Project End: 1992-08-16
• Budget Start: 1992-04-10
• Budget End: 1992-08-16
• Support Year: 1
• Fiscal Year: 1992

Institution

• Name: University of North Carolina Chapel Hill
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Whinna, H C; Lesesky, E B; Monroe, D M et al. (2004) Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. J Thromb Haemost 2:1127-34

Arruda, V R; Hagstrom, J N; Deitch, J et al. (2001) Posttranslational modifications of recombinant myotube-synthesized human factor IX. Blood 97:130-8

Camire, R M; Larson, P J; Stafford, D W et al. (2000) Enhanced gamma-carboxylation of recombinant factor X using a chimeric construct containing the prothrombin propeptide. Biochemistry 39:14322-9

Larson, P J; Camire, R M; Wong, D et al. (1998) Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles. Biochemistry 37:5029-38

Carew, J A; Pollak, E S; High, K A et al. (1998) Severe factor VII deficiency due to a mutation disrupting an Sp1 binding site in the factor VII promoter. Blood 92:1639-45

Wu, S M; Stafford, D W; Frazier, L D et al. (1997) Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase. Blood 89:4058-62

Ambrosini, G; Plescia, J; Chu, K C et al. (1997) Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J Biol Chem 272:8340-5

Chu, K; Wu, S M; Stanley, T et al. (1996) A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism. J Clin Invest 98:1619-25

Hung, H L; High, K A (1996) Liver-enriched transcription factor HNF-4 and ubiquitous factor NF-Y are critical for expression of blood coagulation factor X. J Biol Chem 271:2323-31

Larson, P J; Stanfield-Oakley, S A; VanDusen, W J et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J Biol Chem 271:3869-76