Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049184-03
Application #
2225291
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-04-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Lawrence, D A; Olson, S T; Muhammad, S et al. (2000) Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A. J Biol Chem 275:5839-44
Sjoland, H; Eitzman, D T; Gordon, D et al. (2000) Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 20:846-52
Fay, W P; Parker, A C; Ansari, M N et al. (1999) Vitronectin inhibits the thrombotic response to arterial injury in mice. Blood 93:1825-30
Dougherty, K M; Pearson, J M; Yang, A Y et al. (1999) The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proc Natl Acad Sci U S A 96:686-91
Lavker, R M; Risse, B; Brown, H et al. (1998) Localization of plasminogen activator inhibitor type 2 (PAI-2) in hair and nail: implications for terminal differentiation. J Invest Dermatol 110:917-22
Risse, B C; Brown, H; Lavker, R M et al. (1998) Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2). Histochem Cell Biol 110:559-69
Sherman, P M; Lawrence, D A; Verhamme, I M et al. (1995) Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity. J Biol Chem 270:9301-6
Zheng, X; Saunders, T L; Camper, S A et al. (1995) Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci U S A 92:12426-30
Lawrence, D A; Ginsburg, D; Day, D E et al. (1995) Serpin-protease complexes are trapped as stable acyl-enzyme intermediates. J Biol Chem 270:25309-12
Shore, J D; Day, D E; Francis-Chmura, A M et al. (1995) A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism. J Biol Chem 270:5395-8

Showing the most recent 10 out of 11 publications