Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049211-04
Application #
2225325
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Pathology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Nordskog, B K; Reagan Jr, J W; St Clair, R W (1999) Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux. J Lipid Res 40:1806-17
Liu, M; St Clair, R W; Subbaiah, P V (1998) Impaired function of lecithin:cholesterol acyltransferase in atherosclerosis-susceptible White Carneau pigeons: possible effects on metabolism of oxidized phospholipids. J Lipid Res 39:245-54
Seo, T; St Clair, R W (1997) Heparan sulfate proteoglycans mediate internalization and degradation of beta-VLDL and promote cholesterol accumulation by pigeon macrophages. J Lipid Res 38:765-79
St Clair, R W (1997) Effects of estrogens on macrophage foam cells: a potential target for the protective effects of estrogens on atherosclerosis. Curr Opin Lipidol 8:281-6
Seo, T; Wang, H C; Feldman, S R et al. (1997) Characterization of alpha 2-macroglobulin receptor low density lipoprotein receptor-related protein (alpha 2 MR/LRP) in White Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism. Biochim Biophys Acta 1344:171-88
Sulistiyani; St Clair, R W (1997) Effect of 17 beta-estradiol on metabolism of acetylated low-density lipoprotein by THP-1 macrophages in culture. Arterioscler Thromb Vasc Biol 17:1691-700
St Clair, R W; Yancey, P G; Leight, M A (1995) Macrophage cholesterol balance. A potential site of genetic control of susceptibility to atherosclerosis. Ann N Y Acad Sci 748:264-75;discussion 275-6
Yancey, P G; St Clair, R W (1994) Mechanism of the defect in cholesteryl ester clearance from macrophages of atherosclerosis-susceptible White Carneau pigeons. J Lipid Res 35:2114-29