Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL050291-03
Application #
2371097
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-09-01
Project End
1999-07-31
Budget Start
1996-11-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Pathology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Bossi, Fleur; Fischetti, Fabio; Regoli, Domenico et al. (2009) Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. J Allergy Clin Immunol 124:1303-10.e4
Ghebrehiwet, Berhane; Feng, Xiaodong; Kumar, Rajeev et al. (2003) Complement component C1q induces endothelial cell adhesion and spreading through a docking/signaling partnership of C1q receptors and integrins. Int Immunopharmacol 3:299-310
Kumar, Rajeev; Peerschke, Ellinor I B; Ghebrehiwet, Berhane (2002) Zinc induces exposure of hydrophobic sites in the C-terminal domain of gC1q-R/p33. Mol Immunol 39:69-75
Feng, Xiaodong; Tonnesen, Marcia G; Peerschke, Ellinor I B et al. (2002) Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading. J Immunol 168:2441-8
Ghebrehiwet, Berhane; Jesty, Jolyon; Peerschke, Ellinor I B (2002) gC1q-R/p33: structure-function predictions from the crystal structure. Immunobiology 205:421-32
Szabo, J; Cervenak, L; Toth, F D et al. (2001) Soluble gC1q-R/p33, a cell protein that binds to the globular ""heads"" of C1q, effectively inhibits the growth of HIV-1 strains in cell cultures. Clin Immunol 99:222-31
Peerschke, E I; Ghebrehiwet, B (2001) Human blood platelet gC1qR/p33. Immunol Rev 180:56-64
Nguyen, T; Ghebrehiwet, B; Peerschke, E I (2000) Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with platelets. Infect Immun 68:2061-8
Peerschke, E I (1999) Maintenance of GPIIb-IIIa avidity supporting ""irreversible"" fibrinogen binding is energy-dependent. J Lab Clin Med 134:398-404
Lu, P D; Galanakis, D K; Ghebrehiwet, B et al. (1999) The receptor for the globular ""heads"" of C1q, gC1q-R, binds to fibrinogen/fibrin and impairs its polymerization. Clin Immunol 90:360-7

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