Abstract

One of the key manifestations in HIV infection is thrombocytopenia which was described even prior to the discovery of HIV. This grantee is investigating the role of various gene products in regulation of megakaryocytopoiesis and the effect of HIV infection on megakaryocytic cells. One such gene product, termed megakaryocyte associated tyrosine kinase, will be studied with respect to its expression in HIV infection. Initial results indicated an inhibitory effect of HIV on expression of these genes. The results of these studies will provide one mechanism for retroviral impairment of megakaryocyte growth and maturation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051456-02
Application #
2228222
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-09-30
Project End
1999-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Avraham, Hava; Avraham, Shalom; Zagozdzon, Radoslaw (2004) Use of antisense oligonucleotide technology to investigate signaling pathways in megakaryocytes. Methods Mol Biol 273:397-406
Lee, Byeong-Chel; Cha, Kiweon; Avraham, Shalom et al. (2004) Microarray analysis of differentially expressed genes associated with human ovarian cancer. Int J Oncol 24:847-51
Avraham, Hava Karsenty; Lee, Tae-Hee; Koh, Youngho et al. (2003) Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem 278:36661-8
Li, Huchun; Lee, Tae-Hee; Avraham, Hava (2002) A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. J Biol Chem 277:20965-73
Zagozdzon, Radoslaw; Bougeret, Cecile; Fu, Yigong et al. (2002) Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. Int J Oncol 21:1347-52
McShan, Gina D; Zagozdzon, Radoslaw; Park, Shin-Young et al. (2002) Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. Int J Oncol 21:197-205
Lee, Tae-Hee; Avraham, Hava; Lee, Seung-Hoon et al. (2002) Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. J Biol Chem 277:10445-51
Zhang, X F; Wang, J F; Matczak, E et al. (2001) Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. Blood 97:3342-8
Zrihan-Licht, S; Fu, Y; Settleman, J et al. (2000) RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene 19:1318-28
Park, S Y; Avraham, H; Avraham, S (2000) Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation. J Biol Chem 275:19768-77

Showing the most recent 10 out of 39 publications