It is proposed to continue studies of oxidative damage and related phenomena in coronary heart disease (CHD) risk in 3650 black and white men and women, ancillary to the NHLBI's CARDIA project. In 2005-2006, 20 years after baseline at ages 18-30, CARDIA will assess the near-middle aged participants for subclinical CHD by measuring coronary artery calcification (CAC) and carotid artery intimal medial thickening, as well as other factors that may affect atherogenesis (body fatness, blood pressure, circulating lipids, C-reactive protein (CRP), glucose, insulin and albuminuria). Recently this ancillary study demonstrated a relationship between elevated levels of circulating F2-isoprostanes (oxidative damage) and CAC that was independent of CRP, yielding the important insight that a systemic increase in oxidative burden in excess of. that formed by atherosclerosis itself is present in early coronary calcification in humans. The proposed renewal of the ancillary study will collect 23 ml blood and 10 ml urine at CARDIA year 20, do biochemistries in these and preexisting samples, and do data analyses. Blood F2-isoprostanes, phospholipase A2, superoxide dismutase, and carotenoids and tocopherols will be remeasured, and oxidized LDL and myeloperoxidase added, permitting study of associations of antioxidant and oxidative damage levels and their changes with existence and development of subclinical macrovascular disease in this still-young group. Study of gamma glutamyl transferase (GGT), the primary function of which is to regenerate glutathione, an intracellular antioxidant will continue. This ancillary study has shown GGT to be strongly predictive of diabetes and hypertension. In this connection, glutathione and glutathione peroxidase will be assessed. Hemoglobin A1 c, an indicator of glycemia that has been associated with oxidative stress, will be added. By measuring several antioxidants and oxidative damage in different compounds, this project will continue to test the association of antioxidants and oxidative damage with early/subclinical CHD and offer new avenues for CHD prevention. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053560-10
Application #
6931156
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Wei, Gina
Project Start
2000-04-01
Project End
2008-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
10
Fiscal Year
2005
Total Cost
$626,433
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Lane-Cordova, Abbi D; Gunderson, Erica P; Carnethon, Mercedes R et al. (2018) Pre-pregnancy endothelial dysfunction and birth outcomes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Hypertens Res 41:282-289
Granados, Andrea; Gebremariam, Achamyeleh; Gidding, Samuel S et al. (2018) Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study. Diabetes Obes Metab :
Yoon, Cynthia Yursun; Steffen, Lyn M; Gross, Myron D et al. (2017) Circulating Cellular Adhesion Molecules and Cognitive Function: The Coronary Artery Risk Development in Young Adults Study. Front Cardiovasc Med 4:37
Carson, April P; Muntner, Paul; Selvin, Elizabeth et al. (2016) Do glycemic marker levels vary by race? Differing results from a cross-sectional analysis of individuals with and without diagnosed diabetes. BMJ Open Diabetes Res Care 4:e000213
Jacobs Jr, David R; Kalhan, Ravi (2016) Healthy Diets and Lung Health. Connecting the Dots. Ann Am Thorac Soc 13:588-90
Black, C N; Penninx, B W J H; Bot, M et al. (2016) Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study. Transl Psychiatry 6:e743
Sharma, Shishir; Colangelo, Laura A; Lloyd-Jones, Donald et al. (2016) Longitudinal associations between adiponectin and cardiac structure differ by hypertensive status: Coronary Artery Risk Development in Young Adults. Cardiovasc Endocrinol 5:57-63
Odegaard, Andrew O; Jacobs Jr, David R; Sanchez, Otto A et al. (2016) Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes. Cardiovasc Diabetol 15:51
Kan, Mengyuan; Auer, Paul L; Wang, Gao T et al. (2016) Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project. Eur J Hum Genet 24:1181-7
Carson, April P; Steffes, Michael W; Carr, J Jeffrey et al. (2015) Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes. Diabetes Care 38:66-71

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