Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054775-02
Application #
2233230
Study Section
Metabolism Study Section (MET)
Project Start
1995-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Palo Alto Medical Foundation Research Institute
Department
Type
DUNS #
622276137
City
Palo Alto
State
CA
Country
United States
Zip Code
94301
Chen, Jean Y; Levy-Wilson, Beatriz; Goodart, Sheryl et al. (2002) Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. J Biol Chem 277:42588-95
Antes, T J; Levy-Wilson, B (2001) HNF-3 beta, C/EBP beta, and HNF-4 act in synergy to enhance transcription of the human apolipoprotein B gene in intestinal cells. DNA Cell Biol 20:67-74
Antes, T J; Goodart, S A; Chen, W et al. (2001) Human apolipoprotein B gene intestinal control region. Biochemistry 40:6720-30
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Antes, T J; Chen, J; Cooper, A D et al. (2000) The nuclear matrix protein CDP represses hepatic transcription of the human cholesterol-7alpha hydroxylase gene. J Biol Chem 275:26649-60
Goodart, S A; Huynh, C; Chen, W et al. (1999) Expression of the human cholesterol 7alpha-hydroxylase gene in transgenic mice. Biochem Biophys Res Commun 266:454-9
Chen, J; Cooper, A D; Levy-Wilson, B (1999) Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter. Biochem Biophys Res Commun 260:829-34
Cooper, A D; Chen, J; Botelho-Yetkinler, M J et al. (1997) Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7alpha-hydroxylase gene. J Biol Chem 272:3444-52