The overall goal of this project is to determine whether autotransplantation of skeletal myoblasts into scarred or failing myocardium will lead to long term survival of the myoblast and improvement in systolic and diastolic contractile function. The Principal Investigator plans to use a model of cryoablation injury to the ventricle injecting the myoblasts into the area of damage. In the first aim she will develop a method of labeling the transplanted cells so that they could be detected late and to facilitate determination of longevity. In the second aim, she will determine regional wall motion abnormalities in the area of myoblast transplantation and determine the microenvironment to which the cells are transplanted. In the third aim, she will determine whether the viability of harvested skeletal myoblasts is altered by the presence of congestive heart failure. She will also test the efficacy of myoblast transplantation in a model of coronary ischemia.
| Robertson, Matthew J; Dries-Devlin, Jessica L; Kren, Stefan M et al. (2014) Optimizing recellularization of whole decellularized heart extracellular matrix. PLoS One 9:e90406 |
| Seguin, Agathe; Baccari, Sonia; Holder-Espinasse, Muriel et al. (2013) Tracheal regeneration: evidence of bone marrow mesenchymal stem cell involvement. J Thorac Cardiovasc Surg 145:1297-1304.e2 |
| Davis, Bryce H; Morimoto, Yoshihisa; Sample, Chris et al. (2012) Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. J Biomech Eng 134:101005 |
| McCue, Jonathan D; Swingen, Cory; Feldberg, Tanya et al. (2008) The real estate of myoblast cardiac transplantation: negative remodeling is associated with location. J Heart Lung Transplant 27:116-23 |
| Zenovich, Andrey G; Taylor, Doris A (2008) Atherosclerosis as a disease of failed endogenous repair. Front Biosci 13:3621-36 |
| Zenovich, A G; Davis, B H; Taylor, D A (2007) Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells. Handb Exp Pharmacol :117-65 |
| Taylor, Doris A; Zenovich, Andrey G (2007) Cell therapy for left ventricular remodeling. Curr Heart Fail Rep 4:3-10 |
| Davis, Bryce H; Schroeder, Thies; Yarmolenko, Pavel S et al. (2007) An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. Ann Biomed Eng 35:1414-24 |
| Ott, Harald C; Brechtken, Johannes; Swingen, Cory et al. (2006) Robotic minimally invasive cell transplantation for heart failure. J Thorac Cardiovasc Surg 132:170-3 |
| Pedrotty, Dawn M; Koh, Jennifer; Davis, Bryce H et al. (2005) Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation. Am J Physiol Heart Circ Physiol 288:H1620-6 |
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