The primary goal of this study is to examine the neuropsychological functioning of emphysema patients undergoing lung volume reduction surgery (MT+LVRS) compared to medical therapy alone (MT). The study will include patients at two clinical sites for the National Emphysema Treatment Trial (NETT). Enhancements of ventilation and functional capacity are expected to contribute to greater long-term improvements in utilization of oxygen in the brain, thereby leading to improvements in cognitive performance greater than those observed among patients who exercise but do not receive LVRS (Specific Aim 1). A health control group will be retested on similar neuropsychological tests in order to control for practice effects (Specific Aim 2). Although we do not expect significant differences in emotional (depression and anxiety) functioning across groups, this study will enable us to evaluate the relationship between emotional status and neuropsychological scores in the MT+ LVRS and MT groups following randomization. In addition, since major neurological events are more likely following surgery, and major neurological events affect cognitive function, we will evaluate the incidence of neurological events in our sample and will determine the degree to which neurological events are associated with cognitive function (Specific Aim 3). No studies have examined the relationship between change in cognition and improve quality of life in COPD patients following LVRS surgery, therefore, we aim to explore these associations in Specific Aim 4. We propose to compare changes following LVRS and MT by examining 84 NETT patients (42 in MT, 42 in LVRS) at three times points (baseline, post 6-10 week medical treatment MT, and 6 months post MT or LVRS randomization) using select neuropsychological, psychological, neurological and QoL tests. Forty normal controls will be tested at baseline and 6-10 weeks follow- up.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL063761-02
Application #
6351587
Study Section
Special Emphasis Panel (ZRG1-RPHB-3 (01))
Program Officer
Croxton, Thomas
Project Start
2000-02-01
Project End
2003-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
2
Fiscal Year
2001
Total Cost
$322,704
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Kozora, Elizabeth; Emery, Charles F; Zhang, Lening et al. (2011) Sequential cognitive skills in emphysema patients following lung volume reduction surgery: a 2-year longitudinal study. J Cardiopulm Rehabil Prev 31:386-91
Green, Marquisha R; Emery, Charles F; Kozora, Elizabeth et al. (2011) Religious and spiritual coping and quality of life among patients with emphysema in the National Emphysema Treatment Trial. Respir Care 56:1514-21
Kozora, Elizabeth; Emery, Charles F; Zhang, Lening et al. (2010) Improved neurobehavioral functioning in emphysema patients following medical therapy. J Cardiopulm Rehabil Prev 30:251-9
Ashmore, Jamile A; Emery, Charles F; Hauck, Emily R et al. (2005) Marital adjustment among patients with chronic obstructive pulmonary disease who are participating in pulmonary rehabilitation. Heart Lung 34:270-8
Kozora, Elizabeth; Emery, Charles F; Ellison, Misoo C et al. (2005) Improved neurobehavioral functioning in emphysema patients following lung volume reduction surgery compared with medical therapy. Chest 128:2653-63