""""""""Genome-wide association studies of adiposity in Samoans"""""""" The goal of this new application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans. We will use genome-wide association methods to take advantage of newer more powerful techniques to identify single nucleotide polymorphism (SNP) variants that are associated with adiposity phenotypes. We will conduct these studies using a population sample of 2,500 adults from rural areas of Samoa, an independent nation experiencing the nutritional transition. We will replicate the findings from our genome-wide association studies of important SNPs by further analysis in three different study samples: an independent sample of 2,500 Samoans from earlier studies in American Samoa and Samoa, and 1,500 adults from Croatia and 1,000 adults from China. We will then determine the sequences of the important genes and determine the specific genetic variants in the sequenced genes that are associated with obesity in these three samples. Finally, we will explore gene-environment interactions, taking advantage of identified genetic variants in the sequenced regions and the substantial environmental heterogeneity in lifestyle and nutritional behaviors within Samoa. The knowledge gained from this research will aid the development of interventions on obesity amon Samoans including those in the US and may be generalizable to other Pacific Islander groups.

Public Health Relevance

The goal of this application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans using genome-wide association methods. Genotyping will be performed using a panel of approximately 900,000 SNPs, and adiposity phenotypes will be collected from 2,500 adult Samoans residing in rural regions of Samoa.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL093093-01A1
Application #
7654549
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Papanicolaou, George
Project Start
2009-09-01
Project End
2014-05-31
Budget Start
2009-09-01
Budget End
2010-05-31
Support Year
1
Fiscal Year
2009
Total Cost
$1,413,321
Indirect Cost
Name
Brown University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Maredia, H; Hawley, N L; Lambert-Messerlian, G et al. (2018) Reproductive health, obesity, and cardiometabolic risk factors among Samoan women. Am J Hum Biol 30:e23106
Linhart, Christine; Naseri, Take; Lin, Sophia et al. (2018) Continued increases in blood pressure over two decades in Samoa (1991-2013); around one-third of the increase explained by rising obesity levels. BMC Public Health 18:1122
Wang, Dongqing; Hawley, Nicola L; Thompson, Avery A et al. (2017) Dietary Patterns Are Associated with Metabolic Outcomes among Adult Samoans in a Cross-Sectional Study. J Nutr 147:628-635
Linhart, Christine; Naseri, Take; Lin, Sophia et al. (2017) Tobacco smoking trends in Samoa over four decades: can continued globalization rectify that which it has wrought? Global Health 13:31
Lin, Sophia; Naseri, Take; Linhart, Christine et al. (2017) Diabetes incidence and projections from prevalence surveys in Samoa over 1978-2013. Int J Public Health 62:687-694
NCD Risk Factor Collaboration (NCD-RisC) (2017) Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19ยท1 million participants. Lancet 389:37-55
Lin, S; Naseri, T; Linhart, C et al. (2017) Trends in diabetes and obesity in Samoa over 35 years, 1978-2013. Diabet Med 34:654-661
Falabella, Micol; Sun, Linqing; Barr, Justin et al. (2017) Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events In Vivo. G3 (Bethesda) 7:3533-3542
Maredia, Hasina; Lambert-Messerlian, Geralyn M; Palomaki, Glenn E et al. (2016) Cut-off levels for hyperandrogenemia among Samoan women: An improved methodology for deriving normative data in an obese population. Clin Biochem 49:782-6
Minster, Ryan L; Hawley, Nicola L; Su, Chi-Ting et al. (2016) A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet 48:1049-1054

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