Overweight and obesity during childhood strongly influence the risk of cardiovascular diseases and diabetes in adulthood. This study will be the first national study of overweight, obesity and cardiometabolic risk factors among Hispanic children (ages 8-14) living in the U.S.
Specific Aims : (1) Evaluate the influence of youth acculturation and intergenerational differences in acculturation between youth and parents on youth's lifestyle behaviors and their cardiometabolic risk profiles;(2) Test the association of parenting strategies and practices with children's lifestyle behaviors and cardiometabolic risk profiles;and, (3) Assess the influence of youths'psychosocial functioning on youth lifestyle behaviors and cardiometabolic risk profiles. Research Design: Researchers from five universities will recruit a sample of 1,600 boys and girls ages 8 to 14 with at least one parent participating in the Hispanic Community Health Study (HCHS/Study of Latino Health (SOL). SOL is a multi-center epidemiologic study of 16,000 Hispanic/Latino adults (ages 18-74) designed to determine the role of acculturation in the prevalence and development of cardiovascular diseases and diabetes, and to identify risk factors playing a protective or harmful role in determining the health of Hispanics/Latino adults. Data Collection: Participants in the proposed SOL Children's Study (SOL-Youth) will undergo a single 3-hour clinical examination and seven days of physical activity monitoring. During the clinical examination, youth will complete an interviewer-administered questionnaire assessing acculturation, pubertal development, psychological functioning, physical activity, diet, and family meal patterns. A substudy will be conducted to provide validation of participants'self reports of pubertal status. Clinic staff will collect anthropometric, blood pressure, and blood lipid data from youth and participants will complete an aerobic fitness test. Data on novel biomarkers, including measures of endothelial dysfunction, inflammation, and adipocytokines, will also be obtained. Data on the parents of participating youth will be obtained primarily from existing data collected by the adult HCHS/SOL study, combined with new data obtained from parents on their children's medical histories and parenting strategies to promote a healthy home environment. Analyses: Statisticians at the coordinating center will analyze centrally stored data proceeding from bivariate analyses of the relationship between acculturation measures and our primary outcomes of interest - cardiometabolic risk factors and life style behaviors - to multivariate analyses using regression techniques. Implications: Detailed parent and child data on risk and protective factors will provide the basis for the development of prevention and intervention programs to improve the health of Hispanic/Latino children from middle childhood to early adulthood. Results will be disseminated to professional and lay communities through journal articles, conference presentations, and the press. A limited use dataset will also be publicly released.

Public Health Relevance

U.S. Latino youth are more overweight or obese than non-Hispanic white youth and are at risk for lasting cardiovascular complications into adulthood. The present study will study a wide range of cultural factors (e.g., family environment, physical, social) associated with obesity in a sample of 1,600 Latino boys and girls aged 8-14 years old from the Bronx, NY;Chicago, IL;Miami, FL and San Diego, CA. Findings from our study will inform practice and policy efforts to develop programs to prevent obesity in Latino youth and thus improve the health of future generations.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Aviles-Santa, Larissa
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University of North Carolina Chapel Hill
Biostatistics & Other Math Sci
Schools of Public Health
Chapel Hill
United States
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Strizich, Garrett; Kaplan, Robert C; Sotres-Alvarez, Daniela et al. (2018) Objectively Measured Sedentary Behavior, Physical Activity, and Cardiometabolic Risk in Hispanic Youth: Hispanic Community Health Study/Study of Latino Youth. J Clin Endocrinol Metab 103:3289-3298
Isasi, Carmen R; Strizich, Garrett M; Kaplan, Robert et al. (2018) The association of cardiorespiratory fitness with cardiometabolic factors, markers of inflammation, and endothelial dysfunction in Latino youth: findings from the Hispanic Community Children's Health Study/Study of Latino Youth. Ann Epidemiol 28:583-589.e3
Perreira, Krista M; Marchante, Ashley N; Schwartz, Seth J et al. (2018) Stress and Resilience: Key Correlates of Mental Health and Substance Use in the Hispanic Community Health Study of Latino Youth. J Immigr Minor Health :
Parrinello, Christina M; Hua, Simin; Carnethon, Mercedes R et al. (2017) Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). J Diabetes Complications 31:836-842
Carnethon, Mercedes R; Ayala, Guadalupe X; Bangdiwala, Shrikant I et al. (2017) Association of cardiovascular risk factors between Hispanic/Latino parents and youth: the Hispanic Community Health Study/Study of Latino Youth. Ann Epidemiol 27:260-268.e2
Gallo, Linda C; Roesch, Scott P; McCurley, Jessica L et al. (2017) Youth and Caregiver Physical Activity and Sedentary Time: HCHS/SOL Youth. Am J Health Behav 41:67-75
Reina, Samantha A; Llabre, Maria M; Vidot, Denise C et al. (2017) Metabolic Syndrome in Hispanic Youth: Results from the Hispanic Community Children's Health Study/Study of Latino Youth. Metab Syndr Relat Disord 15:400-406
Isasi, Carmen R; Hua, Simin; Jung, Molly et al. (2017) The Association of Parental/Caregiver Chronic Stress with Youth Obesity: Findings from the Study of Latino Youth and the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study. Child Obes 13:251-258
Qi, Qibin; Hua, Simin; Perreira, Krista M et al. (2017) Sex Differences in Associations of Adiposity Measures and Insulin Resistance in US Hispanic/Latino Youth: The Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). J Clin Endocrinol Metab 102:185-194
Steinberger, Julia; Daniels, Stephen R; Hagberg, Nancy et al. (2016) Cardiovascular Health Promotion in Children: Challenges and Opportunities for 2020 and Beyond: A Scientific Statement From the American Heart Association. Circulation 134:e236-55

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