Abstract

This research project will define the intracortical patterns of neural activity that underlie visual evoked potentials and the endogenous event related potentials (ERP) associated with discriminative performance. Old world monkeys will be employed as an animal model of human ERP generation. Methods for concurrent recording of field potentials and multiple unit activity (MUA), augmented by current source density (CSD) analysis will be used to examine the effect of manipulating stimulus and task variables on intracortical activity. These studies are intended to bridge the gap between investigations of scalp recorded ERP in humans and the more detailed analyses of intracortical activity that can only be carried out in experimental animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH006723-23
Application #
3374576
Study Section
(BPNB)
Project Start
1978-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
23
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Tenke, Craig E; Kayser, Jürgen (2012) Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions. Clin Neurophysiol 123:2328-45
Fishman, Y I; Reser, D H; Arezzo, J C et al. (1998) Pitch vs. spectral encoding of harmonic complex tones in primary auditory cortex of the awake monkey. Brain Res 786:18-30
Schroeder, C E; Seto, S; Garraghty, P E (1997) Emergence of radial nerve dominance in median nerve cortex after median nerve transection in an adult squirrel monkey. J Neurophysiol 77:522-6
Schroeder, C E; Javitt, D C; Steinschneider, M et al. (1997) N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. Exp Brain Res 114:271-8
Javitt, D C; Steinschneider, M; Schroeder, C E et al. (1996) Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. Proc Natl Acad Sci U S A 93:11962-7
Peterson, N N; Schroeder, C E; Arezzo, J C (1995) Neural generators of early cortical somatosensory evoked potentials in the awake monkey. Electroencephalogr Clin Neurophysiol 96:248-60
Steinschneider, M; Reser, D; Schroeder, C E et al. (1995) Tonotopic organization of responses reflecting stop consonant place of articulation in primary auditory cortex (A1) of the monkey. Brain Res 674:147-52
Schroeder, C E; Seto, S; Arezzo, J C et al. (1995) Electrophysiological evidence for overlapping dominant and latent inputs to somatosensory cortex in squirrel monkeys. J Neurophysiol 74:722-32
Givre, S J; Arezzo, J C; Schroeder, C E (1995) Effects of wavelength on the timing and laminar distribution of illuminance-evoked activity in macaque V1. Vis Neurosci 12:229-39
Simpson, G V; Pflieger, M E; Foxe, J J et al. (1995) Dynamic neuroimaging of brain function. J Clin Neurophysiol 12:432-49

Showing the most recent 10 out of 39 publications