The principal goal of this proposal is to define the anatomical structures and neural activity that underlie the surface recorded Event Related Potentials (ERP) associated with sensory, motor and cognitive processes. These studies utilize unanesthetized, behaving old world monkeys (M. fascicularis), as the closest feasible model for human ERP. After surface mapping of the specific ERP under study, depth recordings are employed to localize the intracranial generators and to define through three- dimensional intracerebral mapping, the relationship between field potentials recorded in the immediate vicinity of the active structures and the surface recorded potentials, which usually represent composite activity from more than one structure. The neural processes within each active structure are further delineated by concurrent recording of field potentials and MUA from closely spaced electrodes, utilizing a moveable multicontact electrode of our own design. Local outward and inward neural transmembrane current flows are estimated from the field potential data, utilizing current source density analysis. Identification of active structures and delineation of regions of enhanced neural metabolism within the structures under electrophysiological analysis is achieved by 2-Deoxyglucose autoradiography prior to sacrifice of each animal. Efforts will be made to identify the neurotransmitters involved in generation of specific ERP features. The initial focus is on the role of GABA in intracortical inhibitory circuitry, employing localized intracortical injections of the GABA antagonist bicuculline. This endeavor will be facilitated by immunocytochemical examination of the distribution of specific neurotransmitters within the brain structures under elecrophysiologic study. Studies will focus on stimulus related laminar patterns of evoked response in striate and extrastriate visual cortex, cerebral activity associated with trained self-initiated hand movements and the potentials related to the performance of visual and auditory discrimination tasks.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH006723-25
Application #
3374574
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1987-07-01
Project End
1990-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
25
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Tenke, Craig E; Kayser, Jürgen (2012) Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions. Clin Neurophysiol 123:2328-45
Fishman, Y I; Reser, D H; Arezzo, J C et al. (1998) Pitch vs. spectral encoding of harmonic complex tones in primary auditory cortex of the awake monkey. Brain Res 786:18-30
Schroeder, C E; Javitt, D C; Steinschneider, M et al. (1997) N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. Exp Brain Res 114:271-8
Schroeder, C E; Seto, S; Garraghty, P E (1997) Emergence of radial nerve dominance in median nerve cortex after median nerve transection in an adult squirrel monkey. J Neurophysiol 77:522-6
Javitt, D C; Steinschneider, M; Schroeder, C E et al. (1996) Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. Proc Natl Acad Sci U S A 93:11962-7
Peterson, N N; Schroeder, C E; Arezzo, J C (1995) Neural generators of early cortical somatosensory evoked potentials in the awake monkey. Electroencephalogr Clin Neurophysiol 96:248-60
Steinschneider, M; Reser, D; Schroeder, C E et al. (1995) Tonotopic organization of responses reflecting stop consonant place of articulation in primary auditory cortex (A1) of the monkey. Brain Res 674:147-52
Schroeder, C E; Seto, S; Arezzo, J C et al. (1995) Electrophysiological evidence for overlapping dominant and latent inputs to somatosensory cortex in squirrel monkeys. J Neurophysiol 74:722-32
Givre, S J; Arezzo, J C; Schroeder, C E (1995) Effects of wavelength on the timing and laminar distribution of illuminance-evoked activity in macaque V1. Vis Neurosci 12:229-39
Simpson, G V; Pflieger, M E; Foxe, J J et al. (1995) Dynamic neuroimaging of brain function. J Clin Neurophysiol 12:432-49

Showing the most recent 10 out of 39 publications