Abstract

We wish to test the idea that subtypes of schizophrenia represent outcomes of different causes rather than variable responses to the same provocation. We intend to explore the distribution in a representative sample, and in the context of a family history of schizophrenia, of two variables: season of birth, and age at onset. I. Season of Birth: A. When compared with patients with schizophrenia who were born during the months of March-November, those born in December, January and February are: 1. less likely to have a poor premorbid history and have affected relatives 2. more likely to be younger at first admission and be born to a mother with a characteristic pattern of spring conception 3. to have had some obstetrical complication 4. differ in signs and symptoms II. Age at Onset: A. The genetic influence will vary according to age. l. There will be an inverse relationship between age at onset of schizophrenia (or age at first hospitalization) and the incidence of affected relatives, the severity of the disease B. The incidence of affected relatives will be particularly high when the index case is a female with age at onset below the median age for adults C. There will be a significant correlation for age at onset within families.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH035712-09
Application #
3375738
Study Section
Special Emphasis Panel (EPSA)
Project Start
1983-05-01
Project End
1992-04-30
Budget Start
1990-05-01
Budget End
1992-04-30
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Muntaner, C; Wolyniec, P; McGrath, J et al. (1998) Arrest among psychotic inpatients: assessing the relationship to diagnosis, gender, number of admissions, and social class. Soc Psychiatry Psychiatr Epidemiol 33:274-82
Muntaner, C; Wolyniec, P; McGrath, J et al. (1995) Differences in social class among psychotic patients at inpatient admission. Psychiatr Serv 46:176-8
Pulver, A E; Karayiorgou, M; Wolyniec, P S et al. (1994) Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet 54:36-43
Pulver, A E; Karayiorgou, M; Lasseter, V K et al. (1994) Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet 54:44-50
Muntaner, C; Wolyniec, P; McGrath, J et al. (1994) Psychotic inpatients' social class and their first admission to state or private psychiatric Baltimore hospitals. Am J Public Health 84:287-9
Karayiorgou, M; Kasch, L; Lasseter, V K et al. (1994) Report from the Maryland Epidemiology Schizophrenia Linkage Study: no evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model. Am J Med Genet 54:345-53
Melton, B; Liang, K Y; Pulver, A E (1994) Extended latent class approach to the study of familial/sporadic forms of a disease: its application to the study of the heterogeneity of schizophrenia. Genet Epidemiol 11:311-27
Muntaner, C; Pulver, A E; McGrath, J et al. (1993) Work environment and schizophrenia: an extension of the arousal hypothesis to occupational self-selection. Soc Psychiatry Psychiatr Epidemiol 28:231-8
Pulver, A E; Liang, K Y; Wolyniec, P S et al. (1992) Season of birth of siblings of schizophrenic patients. Br J Psychiatry 160:71-5
Wolyniec, P S; Pulver, A E; McGrath, J A et al. (1992) Schizophrenia: gender and familial risk. J Psychiatr Res 26:17-27

Showing the most recent 10 out of 18 publications