Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042600-07
Application #
2245487
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1988-04-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arizona
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Waters, S M; Rounseville, M P; Davis, T P (1997) Effect of dopaminergic drugs on processing and degradative neuropeptidase mRNA in rat frontal cortex and caudate-putamen. Brain Res 754:28-34
Waters, S M; Davis, T P (1997) Alterations of peptide metabolism and neuropeptidase activity in senile dementia of the Alzheimer's type. Ann N Y Acad Sci 814:30-9
Mania-Farnell, B L; Botros, I; Day, R et al. (1996) Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines. Peptides 17:47-54
Waters, S M; Konkoy, C S; Davis, T P (1996) Haloperidol and apomorphine differentially affect neuropeptidase activity. J Pharmacol Exp Ther 277:113-20
Konkoy, C S; Waters, S M; Davis, T P (1996) Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex. Eur J Pharmacol 297:47-51
Waters, S M; Konkoy, C S; Davis, T P (1995) Neuropeptide metabolism on intact, regional brain slices: effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation. J Pharmacol Exp Ther 274:783-9
Mania-Farnell, B L; Botros, I W; Davis, T P (1995) Modulation of CCK mRNA in cell lines in response to isoproterenol and retinoic acid. Neuropeptides 29:221-7
Waters, S M; David, T P (1995) Alterations of substance P metabolism and neuropeptidases in Alzheimer's disease. J Gerontol A Biol Sci Med Sci 50:B315-9
Mania-Farnell, B L; Merrill, B J; Yamamura, H I et al. (1994) Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC. Ann N Y Acad Sci 713:446-8
Brownson, E A; Abbruscato, T J; Gillespie, T J et al. (1994) Effect of peptidases at the blood brain barrier on the permeability of enkephalin. J Pharmacol Exp Ther 270:675-80

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