Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH054966-02
Application #
2255403
Study Section
Special Emphasis Panel (SRCM (15))
Project Start
1995-09-01
Project End
2000-04-30
Budget Start
1996-09-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Lafuse, W P; Alvarez, G R; Zwilling, B S (2000) Regulation of Nramp1 mRNA stability by oxidants and protein kinase C in RAW264.7 macrophages expressing Nramp1(Gly169). Biochem J 351 Pt 3:687-96
Wang, T; Lafuse, W P; Zwilling, B S (2000) Regulation of toll-like receptor 2 expression by macrophages following Mycobacterium avium infection. J Immunol 165:6308-13
Kuhn, D E; Baker, B D; Lafuse, W P et al. (1999) Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169. J Leukoc Biol 66:113-9
Howard, A D; Zwilling, B S (1999) Reactivation of tuberculosis is associated with a shift from type 1 to type 2 cytokines. Clin Exp Immunol 115:428-34
Hussain, S; Zwilling, B S; Lafuse, W P (1999) Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor. J Immunol 163:2041-8
Zwilling, B S; Kuhn, D E; Wikoff, L et al. (1999) Role of iron in Nramp1-mediated inhibition of mycobacterial growth. Infect Immun 67:1386-92
Chen, L; Boomershine, C; Wang, T et al. (1999) Synergistic interaction of catecholamine hormones and Mycobacterium avium results in the induction of interleukin-10 mRNA expression by murine peritoneal macrophages. J Neuroimmunol 93:149-55
Boomershine, C S; Lafuse, W P; Zwilling, B S (1999) Beta2-adrenergic receptor stimulation inhibits nitric oxide generation by Mycobacterium avium infected macrophages. J Neuroimmunol 101:68-75
Brown, D H; Lafuse, W P; Zwilling, B S (1998) Host resistance to mycobacteria is compromised by activation of the hypothalamic-pituitary-adrenal axis. Ann N Y Acad Sci 840:773-86
Howard, A D; Trask, O J; Weisbrode, S E et al. (1998) Phenotypic changes in T cell populations during the reactivation of tuberculosis in mice. Clin Exp Immunol 111:309-15

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