Deficits in sensory gating are believed to be involved in a variety of clinical symptoms and disrupted cognitive functions in patients with schizophrenia. The psychological and biological mechanisms of normal and impaired gating, and why some novel antipsychotic medications improve gating while conventional antipsychotics do not, are not well understood. Progress toward understanding neural mechanisms involved in gating can contribute to theory about schizophrenia and to its treatment. A prominent research paradigm for studying gating deficits in schizophrenia involves presentation of a pair of clicks and noninvasive measurement of the P50 component of the associated event-related brain potential. P50 amplitude to the second click is normally reduced substantially from that to the first click, but patients (and some of their family members) commonly show less reduction, i.e. have impaired gating. The proposed project will address three pressing issues surrounding this well-established finding. (1) What are the neural generators of P50? Are they confined to bilateral superior temporal gyrus? (2) How are those generators affected by antipsychotic medication, is the effect equal across the generators, and is the effect different for conventional vs. novel antipsychotics? (3) Is the gating deficit specific to auditory stimuli, or is it cross modal as the literature assumes? This application presents extensive pilot data addressing all three of these issues in hopes of furthering our understanding of impaired sensory gating in schizophrenia.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Meinecke, Douglas L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Biomedical Research Institute of New Mex
United States
Zip Code
Edgar, J C; Fisk 4th, Charles L; Chen, Yu-Han et al. (2018) Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures. Psychophysiology 55:e13074
Edgar, J Christopher; Fisk IV, Charles L; Chen, Yu-Han et al. (2017) By our bootstraps: Comparing methods for measuring auditory 40 Hz steady-state neural activity. Psychophysiology 54:1110-1127
Chen, Yu-Han; Stone-Howell, Breannan; Edgar, J Christopher et al. (2016) Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia. Br J Psychiatry 208:160-7
Caprihan, Arvind; Jones, Thomas; Chen, Hongji et al. (2015) The Paradoxical Relationship between White Matter, Psychopathology and Cognition in Schizophrenia: A Diffusion Tensor and Proton Spectroscopic Imaging Study. Neuropsychopharmacology 40:2248-57
Huang, Ming-Xiong; Huang, Charles W; Robb, Ashley et al. (2014) MEG source imaging method using fast L1 minimum-norm and its applications to signals with brain noise and human resting-state source amplitude images. Neuroimage 84:585-604
Edgar, J Christopher; Chen, Yu-Han; Lanza, Matthew et al. (2014) Cortical thickness as a contributor to abnormal oscillations in schizophrenia? Neuroimage Clin 4:122-9
Edgar, J Christopher; Hunter, Michael A; Huang, Mingxiong et al. (2012) Temporal and frontal cortical thickness associations with M100 auditory activity and attention in healthy controls and individuals with schizophrenia. Schizophr Res 140:250-7
Hunter, Michael; Villarreal, Gerardo; McHaffie, Greg R et al. (2011) Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results. Psychiatry Res 191:138-44
Smith, Ashley K; Edgar, J Christopher; Huang, Mingxiong et al. (2010) Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia. Am J Psychiatry 167:1264-75
Thoma, Robert J; Monnig, Mollie; Hanlon, Faith M et al. (2009) Hippocampus volume and episodic memory in schizophrenia. J Int Neuropsychol Soc 15:182-95

Showing the most recent 10 out of 32 publications